| Type | Description |
|---|---|
| Definition | TSPY like 5 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-04 11:14:00 | TSPYL5, a novel angiogenic regulator, plays a key role in maintaining endothelial integrity and function. | 30471052 |
| 2020-01-18 10:43:00 | PML depletion suppressed POT1 poly-ubiquitination, suggesting an interplay between USP7 and PML to trigger POT1 degradation in TSPYL5-depleted ALT(+) cells. We demonstrate that ALT telomeres need to be protected from POT1 degradation in ALT-associated PML bodies and identify TSPYL5 as an ALT(+) cancer-specific therapeutic target. | 31278054 |
| 2018-09-08 11:09:00 | The expression of spermatogenic phenotypes of TSPY1 defects is independent of variations in TSPYL1 and TSPYL5 in the Han Chinese population. | 28847364 |
| 2018-04-14 10:05:00 | Transcriptome analysis of MUC16 KD showed a downregulation (P = 0.005) of TSPYL5 gene, which encodes for a testis-specific Y-like protein...Also, MUC16 overexpression induced cisplatin and gemcitabine resistance by downregulation of p53 | 28196872 |
| 2018-03-03 10:43:00 | More advanced tumor tissues had an inverse correlation between methylation and TSPYL5 gene or protein expression. TSPYL5 may play a role in sensitivity to chemotherapy likely by modulating pleiotropic protein such as CDKN1A. | 28235398 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
TSYL5_HUMAN
UniprotKB:
Q86VY4
UniParc:
UPI0000210364
EMBL:
AK091445,
BC045630,
AB051537
Ensembl:
ENSG00000180543
KO:
hsa:85453
|
| Nucleutide sequences |
EMBL-CDS:
AAH45630.1,
BAB21841.1,
BAG52362.1
Ensembl_TRS:
ENST00000322128
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000322802
RefSeq:
NP_277047.2
|
| Others |
UniRef100:
UniRef100_Q86VY4
UniRef90:
UniRef90_Q86VY4
UniRef50:
UniRef50_Q86VY4
UniGene:
Hs.173094
CCDS:
CCDS34927.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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