| Type | Description |
|---|---|
| Definition | NAD-dependent histone deacetylase HST3 |
| Date | Results | Publications |
|---|---|---|
| 2017-05-27 11:16:00 | This pathway is functionally relevant to TORC1 signaling since the stress sensitivity of a nonessential TORC1 mutant (tco89Delta) to hydroxyurea and arsenic can be reversed by combining tco89Delta with either hst3Delta, hst4Delta, or sit4Delta Surprisingly, while hst3Delta or hst4Delta rescues the sensitivity tco89Delta has to low concentrations of the TORC1 inhibitor rapamycin, sit4Delta fails to do so | 27343235 |
| 2014-06-28 10:31:00 | an intricate coordination between Hst3 synthesis, genome-wide H3K56 deacetylation by Hst3, and cell cycle-regulated degradation of Hst3 by cyclin-dependent kinases and SCF(Cdc4). | 24648511 |
| 2011-10-01 12:09:00 | Our results suggest that Hst3 and Hst4 regulate replicative lifespan through their ability to deacetylate histone H3-K56 to minimize genomic instability. | 21401809 |
| 2010-01-21 00:00:00 | cells lacking Hst3p in which H3 K56 is constitutively hyperacetylated, exhibit hallmarks of spontaneous DNA damage | 18579506 |
| 2010-01-21 00:00:00 | HST3 HST4 play critical roles in maintaining the hypoacetylated state of lysine56 on histone H3 within silent chromatin. | 18799617 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
HST3_YEAST
UniprotKB:
P53687
UniParc:
UPI000012CDAD
EMBL:
AY723866,
U39062,
BK006948,
X87331,
Z74933
EnsemblGenome:
YOR025W
KO:
sce:YOR025W
|
| Nucleutide sequences |
EMBL-CDS:
AAU09783.1,
DAA10807.1,
CAA99215.1,
AAA81034.1,
CAA60741.1
Gene_ORFName:
OR26.15
EnsemblGenome_TRS:
YOR025W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YOR025W
RefSeq:
NP_014668.1
|
| Others |
UniRef100:
UniRef100_P53687
UniRef90:
UniRef90_P53687
UniRef50:
UniRef50_P53687
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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