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854156 TOP1

854156

TOP1

DNA topoisomerase 1

protein-coding

Saccharomyces cerevisiae S288c

基因描述

Type Description
Definition DNA topoisomerase 1

研究结论

Date Results Publications
2021-04-03 13:38:00 Topoisomerases Modulate the Timing of Meiotic DNA Breakage and Chromosome Morphogenesis in Saccharomyces cerevisiae. 32152049
2020-01-11 12:08:00 Fob1p recruits DNA topoisomerase I to ribosomal genes locus and contributes to its transcriptional silencing maintenance 30880168
2018-07-07 10:08:00 Studies demonstrate opposing roles of Top1 activity in either promoting or destabilizing genome integrity. Resolution of transcription-associated negative supercoils, for example, prevents pairing of the nascent RNA with the DNA template (R-loops) as well as DNA secondary structure formation. Reduced Top1 levels thus enhance CAG repeat contraction, somatic hypermutation, and class switch recombination. 29177731
2018-04-07 11:40:00 Our findings reveal a requirement for the Smc5/6 complex, including Mms21/Nse2 mediated sumoylation, and topoisomerase-1 (Top1), for maintaining stability of a chromosome having low origin density and suggest a functional cooperation between the Smc5/6 complex and Top1 in maintenance of topologically challenged chromosomes prone to replication fork collapse or accumulation of torsional stress 28204881
2018-04-07 11:22:00 Our findings reveal a functional interplay between Mms21 and Top1 in maintenance of longer chromosomes, and suggest that lack of sumoylation of Mms21 targets coupled with Top1 deficiency is a crucial requirement for accurate inheritance of longer chromosomes. 27872982

名称对应

Type IDs
Synonymous MAK1, MAK17
Gene
UniProtKB-ID: TOP1_YEAST
UniprotKB: P04786
UniParc: UPI000005300B
EMBL: K03077, Z74748, BK006948
EnsemblGenome: YOL006C
KO: sce:YOL006C
Nucleutide sequences
EMBL-CDS: CAA99005.1, DAA10777.1, AAA35162.1
EnsemblGenome_TRS: YOL006C_mRNA
Protein sequencees
EnsemblGenome_PRO: YOL006C
RefSeq: NP_014637.1
Others
UniRef100: UniRef100_P04786
UniRef90: UniRef90_P04786
UniRef50: UniRef50_P04786

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