| Type | Description |
|---|---|
| Definition | DNA topoisomerase 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:38:00 | Topoisomerases Modulate the Timing of Meiotic DNA Breakage and Chromosome Morphogenesis in Saccharomyces cerevisiae. | 32152049 |
| 2020-01-11 12:08:00 | Fob1p recruits DNA topoisomerase I to ribosomal genes locus and contributes to its transcriptional silencing maintenance | 30880168 |
| 2018-07-07 10:08:00 | Studies demonstrate opposing roles of Top1 activity in either promoting or destabilizing genome integrity. Resolution of transcription-associated negative supercoils, for example, prevents pairing of the nascent RNA with the DNA template (R-loops) as well as DNA secondary structure formation. Reduced Top1 levels thus enhance CAG repeat contraction, somatic hypermutation, and class switch recombination. | 29177731 |
| 2018-04-07 11:40:00 | Our findings reveal a requirement for the Smc5/6 complex, including Mms21/Nse2 mediated sumoylation, and topoisomerase-1 (Top1), for maintaining stability of a chromosome having low origin density and suggest a functional cooperation between the Smc5/6 complex and Top1 in maintenance of topologically challenged chromosomes prone to replication fork collapse or accumulation of torsional stress | 28204881 |
| 2018-04-07 11:22:00 | Our findings reveal a functional interplay between Mms21 and Top1 in maintenance of longer chromosomes, and suggest that lack of sumoylation of Mms21 targets coupled with Top1 deficiency is a crucial requirement for accurate inheritance of longer chromosomes. | 27872982 |
| Type | IDs |
|---|---|
| Synonymous | MAK1, MAK17 |
| Gene |
UniProtKB-ID:
TOP1_YEAST
UniprotKB:
P04786
UniParc:
UPI000005300B
EMBL:
K03077,
Z74748,
BK006948
EnsemblGenome:
YOL006C
KO:
sce:YOL006C
|
| Nucleutide sequences |
EMBL-CDS:
CAA99005.1,
DAA10777.1,
AAA35162.1
EnsemblGenome_TRS:
YOL006C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YOL006C
RefSeq:
NP_014637.1
|
| Others |
UniRef100:
UniRef100_P04786
UniRef90:
UniRef90_P04786
UniRef50:
UniRef50_P04786
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
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