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854149 HRD1

854149

HRD1

E3 ubiquitin-protein ligase HRD1

protein-coding

Saccharomyces cerevisiae S288c

基因描述

Type Description
Definition E3 ubiquitin-protein ligase HRD1

研究结论

Date Results Publications
2021-03-13 13:21:00 Overlapping function of Hrd1 and Ste24 in translocon quality control provides robust channel surveillance. 33033070
2020-04-18 13:02:00 Identification of two binding sites for misfolded proteins in Hrd1, a low-affinity luminal site and a high-affinity cytoplasmic site formed following auto-ubiquitination of specific lysine residues in Hrd1's RING domain. The affinity difference between the luminal and cytoplasmic binding sites may provide the initial driving force for substrate movement through Hrd1. 32094691
2017-12-09 11:20:00 cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3: results suggest that Hrd1 forms a retro-translocation channel for the movement of misfolded polypeptides through the endoplasmic reticulum membrane 28682307
2017-04-20 16:22:00 Hrd1 is required for ER to cytosol retrotranslocation of ricin A chain, independently of its ubiquitin ligase activity 20519439
2017-04-20 16:20:00 Hrd1p dislocates ricin A chain to the cytosol from the ER lumen, in a manner independent of its E3 ubiquitin ligase activity. 20519439

名称对应

Type IDs
Synonymous DER3
Gene
UniProtKB-ID: HRD1_YEAST
UniprotKB: Q08109
UniParc: UPI000006C0B7
EMBL: Z74755, BK006948
EnsemblGenome: YOL013C
KO: sce:YOL013C
Nucleutide sequences
EMBL-CDS: CAA99012.1, DAA10770.1
EnsemblGenome_TRS: YOL013C_mRNA
Protein sequencees
EnsemblGenome_PRO: YOL013C
RefSeq: NP_014630.1
Others
UniRef100: UniRef100_Q08109
UniRef90: UniRef90_Q08109
UniRef50: UniRef50_Q08109

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