| Type | Description |
|---|---|
| Definition | E3 ubiquitin-protein ligase HRD1 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:21:00 | Overlapping function of Hrd1 and Ste24 in translocon quality control provides robust channel surveillance. | 33033070 |
| 2020-04-18 13:02:00 | Identification of two binding sites for misfolded proteins in Hrd1, a low-affinity luminal site and a high-affinity cytoplasmic site formed following auto-ubiquitination of specific lysine residues in Hrd1's RING domain. The affinity difference between the luminal and cytoplasmic binding sites may provide the initial driving force for substrate movement through Hrd1. | 32094691 |
| 2017-12-09 11:20:00 | cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3: results suggest that Hrd1 forms a retro-translocation channel for the movement of misfolded polypeptides through the endoplasmic reticulum membrane | 28682307 |
| 2017-04-20 16:22:00 | Hrd1 is required for ER to cytosol retrotranslocation of ricin A chain, independently of its ubiquitin ligase activity | 20519439 |
| 2017-04-20 16:20:00 | Hrd1p dislocates ricin A chain to the cytosol from the ER lumen, in a manner independent of its E3 ubiquitin ligase activity. | 20519439 |
| Type | IDs |
|---|---|
| Synonymous | DER3 |
| Gene |
UniProtKB-ID:
HRD1_YEAST
UniprotKB:
Q08109
UniParc:
UPI000006C0B7
EMBL:
Z74755,
BK006948
EnsemblGenome:
YOL013C
KO:
sce:YOL013C
|
| Nucleutide sequences |
EMBL-CDS:
CAA99012.1,
DAA10770.1
EnsemblGenome_TRS:
YOL013C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YOL013C
RefSeq:
NP_014630.1
|
| Others |
UniRef100:
UniRef100_Q08109
UniRef90:
UniRef90_Q08109
UniRef50:
UniRef50_Q08109
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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