| Type | Description |
|---|---|
| Definition | centromeric DNA-binding histone H3-like protein CSE4 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 11:44:00 | Study revealed that two essential Skp, Cullin, F-box (SCF) ubiquitin ligases defined by the F-box proteins Met30 and Cdc4 cooperatively regulate Cse4 (S. cerevisiae homolog of human centromere protein-A (CENP-A)) proteolysis under normal physiological conditions. Results suggest SCF-Met30/Cdc4-mediated proteolysis of Cse4 is one of the major mechanisms that prevents stable maintenance of Cse4 at non-centromeric regions. | 32032354 |
| 2019-07-27 11:12:00 | Findings suggest chromatin assembly factor-1 can act as a CenH3 chaperone, regulating levels and incorporation of CenH3 in chromatin. | 29522205 |
| 2019-04-13 10:05:00 | data suggested a novel structural transition-based mechanism where conformational flexibility of the Cse4 N terminus can control Cse4 levels in the yeast cell and prevent Cse4 from interacting with kinetochore components at ectopic locations for formation of premature kinetochore assembly. | 30381395 |
| 2019-03-30 12:23:00 | Findings suggest that various E3 ubiquitin ligases collaborate to keep the centromeric DNA-binding histone H3-like protein CSE4 (Cse4) level in check, providing a basis for further delineating the intricate network involved in Cse4 regulation. | 28819127 |
| 2019-01-19 11:41:00 | We showed that heterochromatin mediates centromeric localization of Cse4 by protecting Cse4 from ubiquitin-dependent degradation. | 30089114 |
| Type | IDs |
|---|---|
| Synonymous | CSL2 |
| Gene |
UniProtKB-ID:
CENPA_YEAST
UniprotKB:
P36012
UniParc:
UPI0000128518
EMBL:
Z28049,
U20327,
X71621,
BK006944
EnsemblGenome:
YKL049C
KO:
sce:YKL049C
|
| Nucleutide sequences |
EMBL-CDS:
CAA81884.1,
DAA09108.1,
AAB60309.1
Gene_ORFName:
YKL262
EnsemblGenome_TRS:
YKL049C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YKL049C
RefSeq:
NP_012875.2
|
| Others |
UniRef100:
UniRef100_P36012
UniRef90:
UniRef90_P36012
UniRef50:
UniRef50_P36012
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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