| Type | Description |
|---|---|
| Definition | DNA-(apurinic or apyrimidinic site) lyase APN1 |
| Date | Results | Publications |
|---|---|---|
| 2015-09-05 11:26:00 | His-83 of Apn1 properly coordinates the active site Zn2+ ion playing a crucial role in catalytic incision stage during DNA repair. | 25766873 |
| 2013-01-26 11:42:00 | Frataxin (YFH1) deficiency in yeast cells leads to increased DNA base oxidation and requirement of Apn1 for DNA damage repair. | 22706278 |
| 2012-12-08 10:59:00 | steady state levels of Apn1 V156E were substantially decreased compared to wild V156 residue plays a critical role in Apn1 stability, but is not involved in catalytic activity. | 22818187 |
| 2010-01-21 00:00:00 | Direct physical evidence that Apn1 not only repair cellular base damage but also prevent break accumulation that can result from abasic sites being channeled into other base excision repair pathway(s). | 18267974 |
| 2010-01-21 00:00:00 | Novel Apn1 substrates alpha-2'-deoxyadenosine and alpha-thymidine play an important role in counteracting oxidative DNA base damage. | 15568813 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
APN1_YEAST
UniprotKB:
P22936
UniParc:
UPI000016837D
EMBL:
BK006944,
S93804,
M33667,
Z28114
EnsemblGenome:
YKL114C
KO:
sce:YKL114C
|
| Nucleutide sequences |
EMBL-CDS:
AAA34429.1,
DAA09044.1,
AAB22003.1,
CAA81954.1
Gene_ORFName:
YKL513
EnsemblGenome_TRS:
YKL114C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YKL114C
RefSeq:
NP_012808.1
|
| Others |
UniRef100:
UniRef100_P22936
UniRef90:
UniRef90_P22936
UniRef50:
UniRef50_P22936
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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