| Type | Description |
|---|---|
| Definition | translation initiation factor eIF2 subunit alpha |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:28:00 | eIF2alpha interactions with mRNA control accurate start codon selection by the translation preinitiation complex. | 32955564 |
| 2019-06-22 12:06:00 | Data show that translation initiation factor 2alpha [eukaryotic translation initiation factor 2alpha (eIF2alpha; sui2) was phosphorylated at serine51 (Ser51) by of eIF2alpha kinase and downregulated cellular protein synthesis. | 30070006 |
| 2019-06-15 12:28:00 | Study used single-particle electron cryomicroscopy to resolve the structures of phosphorylated (eIF2alphaP) and unphosphorylated (eIF2) from Saccharomyces cerevisiae bound with its nucleotide exchange factor eIF2B. The structures reveal that eIF2 undergoes large rearrangements to promote binding of eIF2alpha to the regulatory core of eIF2B comprised of the eIF2B alpha, beta and delta subunits. | 31086188 |
| 2018-01-13 14:14:00 | These data uncover competition between eIF2B and eIF5 for ternary complexes and identify that phosphorylated eIF2-GTP translation initiation intermediate complexes can be inhibited by eIF2B. | 28315520 |
| 2015-02-14 12:54:00 | Translation elongation factor 1A mutants with altered actin bundling activity show reduced aminoacyl-tRNA binding and alter initiation via eIF2alpha phosphorylation. | 24936063 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
IF2A_YEAST
UniprotKB:
P20459
UniParc:
UPI00000530CA
EMBL:
X87611,
M25552,
AY557876,
Z49507,
BK006943
EnsemblGenome:
YJR007W
KO:
sce:YJR007W
|
| Nucleutide sequences |
EMBL-CDS:
CAA60929.1,
AAA70332.1,
CAA89529.1,
AAS56202.1,
DAA08798.1
Gene_ORFName:
J1429
EnsemblGenome_TRS:
YJR007W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YJR007W
RefSeq:
NP_012540.3
|
| Others |
UniRef100:
UniRef100_P20459
UniRef90:
UniRef90_P20459
UniRef50:
UniRef50_P20459
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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