| Type | Description |
|---|---|
| Definition | Net1p |
| Date | Results | Publications |
|---|---|---|
| 2020-08-01 10:16:00 | In Saccharomyces cerevisiae Hog1 delays mitotic exit when cells are stressed during metaphase. Hog1 phosphorylates the nucleolar protein Net1, altering its affinity for the phosphatase Cdc14, whose activity is essential for mitotic exit and completion of the cell cycle. Saccharomyces cerevisiae strain with mutant Net1 that cannot be phosphorylated by Hog1 displays reduced viability upon osmostress. | 32265285 |
| 2019-03-30 11:06:00 | Results describe the C-terminal region of Net1 as an activator of RNA polymerase I transcription in baker's yeast. In the absence of this activator RNA polymerase I transcription is downregulated and cell proliferation is strongly impaired. Strikingly, this activator might be conserved in human cells, which points to a general mechanism. | 30802237 |
| 2010-01-21 00:00:00 | results show that the FEAR network acts in part by stimulating phosphorylation of Net1 by Clb-Cdk, which directly weakens the interaction of Cdc14 with Net1, allowing for Cdc14 activation and mitotic exit | 15273393 |
| 2010-01-21 00:00:00 | Results show that PP2A(Cdc55) phosphatase keeps Net1 underphosphorylated in metaphase, and that separase interacts with and downregulates PP2A(Cdc55), thereby facilitating Cdk-dependent Net1 phosphorylation. | 16713564 |
| 2010-01-21 00:00:00 | genes SRM5/CDC28, SRM12/HFI1/ADA1, and SRM8/NET1 are involved in the formation of a cell response to DNA damage, and in checkpoint regulation in particular. | 19507699 |
| Type | IDs |
|---|---|
| Synonymous | CFI1, ESC5, SRM8 |
| Gene |
UniProtKB-ID:
NET1_YEAST
UniprotKB:
P47035
UniParc:
UPI0000052F6F
EMBL:
BK006943,
Z49351
EnsemblGenome:
YJL076W
KO:
sce:YJL076W
|
| Nucleutide sequences |
EMBL-CDS:
DAA08724.1,
CAA89367.1
Gene_ORFName:
J1038
EnsemblGenome_TRS:
YJL076W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YJL076W
RefSeq:
NP_012459.1
|
| Others |
UniRef100:
UniRef100_P47035
UniRef90:
UniRef90_P47035
UniRef50:
UniRef50_P47035
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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