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853353 SRS2

853353

SRS2

DNA helicase SRS2

protein-coding

Saccharomyces cerevisiae S288c

基因描述

Type Description
Definition DNA helicase SRS2

研究结论

Date Results Publications
2020-01-25 10:17:00 Srs2 C-terminal Rad51 interaction domain is essential for crossover control in S. cerevisiae. 31142613
2019-07-27 12:08:00 DNA helicase domain of Saccharomyces cerevisiae yeast Srs2 protein is needed to deal with DNA damage and assist in DNA replication during vegetative growth and in meiosis. The interactions of Srs2 with Rad51 Recombinase and proliferating cell nuclear Antigen PCNA are dispensable for the main role of Srs2. 30018112
2018-09-22 11:48:00 Two main activities of Srs2, strippase and helicase, counteract toxic joint intermediates formed during break-induced replication by preventing their formation and promoting their disruption, respectively. 29176630
2018-07-28 12:19:00 Srs2 rapidly disrupts small heteroduplex DNA joints bound to Rad51 filaments. 29241544
2018-02-17 10:48:00 These data establish a biochemical mechanism for the role of Srs2 in crossover suppression by promoting synthesis-dependent strand annealing through disruption of DNA polymerase delta-extended D-loops. 28535142

名称对应

Type IDs
Synonymous HPR5
Gene
UniProtKB-ID: SRS2_YEAST
UniprotKB: P12954
UniParc: UPI0000168360
EMBL: X77087, BK006943, X15665, Z49367
EnsemblGenome: YJL092W
KO: sce:YJL092W
Nucleutide sequences
EMBL-CDS: CAA89385.1, DAA08708.1, CAA33706.1, CAA54361.1
Gene_ORFName: J0913
EnsemblGenome_TRS: YJL092W_mRNA
Protein sequencees
EnsemblGenome_PRO: YJL092W
RefSeq: NP_012443.1
Others
UniRef100: UniRef100_P12954
UniRef90: UniRef90_P12954
UniRef50: UniRef50_P12954

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