| Type | Description |
|---|---|
| Definition | E3 ubiquitin-protein ligase UBR1 |
| Date | Results | Publications |
|---|---|---|
| 2019-03-23 12:00:00 | Altered substrate recognition by Ubr1 accelerates proteasomal degradation of misfolded as well as native proteins at the endoplasmic reticulum membrane and in the cytosol. We term this pathway stress-induced homeostatically regulated protein degradation (SHRED) and propose that it promotes physiological adaptation. | 29861160 |
| 2017-03-25 10:20:00 | In addition to the E3 ubiquitin ligase Ubr1, we identified the prefoldin chaperone subunit Gim3 as an important quality control factor. We found that Gim3 interacted with the Guk1 mutant allele and propose that prefoldin promotes the degradation of the unstable model substrate by maintaining the solubility of the misfolded protein | 27448207 |
| 2015-05-09 12:18:00 | The major ubiquitin ligase targeting the superfluous Fas2 subunit to the proteasome is Ubr1. The ubiquitin-conjugating enzymes Ubc2 and Ubc4 assist the degradation process. | 25564609 |
| 2013-11-30 11:18:00 | Ubr1 Is Present at the endoplasmic reticulum membrane of wild-type cells and becomes a ligase for ER-associated protein degradation of Ste6* under heat and ethanol stress. | 23988329 |
| 2012-10-13 11:32:00 | Data show that ubiquitin-protein ligases Ubr1 and Ubr2 have opposing roles in Ste11DeltaNK444R-GFP aggregation. | 22593585 |
| Type | IDs |
|---|---|
| Synonymous | PTR1 |
| Gene |
UniProtKB-ID:
UBR1_YEAST
UniprotKB:
P19812
UniParc:
UPI0000137A06
EMBL:
Z72969,
X99074,
BK006941,
X53747
EnsemblGenome:
YGR184C
KO:
sce:YGR184C
|
| Nucleutide sequences |
EMBL-CDS:
CAA97210.1,
CAA67528.1,
CAA37779.1,
DAA08278.1
Gene_ORFName:
G7168
EnsemblGenome_TRS:
YGR184C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YGR184C
RefSeq:
NP_011700.1
|
| Others |
UniRef100:
UniRef100_P19812
UniRef90:
UniRef90_P19812
UniRef50:
UniRef50_P19812
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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