| Type | Description |
|---|---|
| Definition | E2 ubiquitin-conjugating protein RAD6 |
| Date | Results | Publications |
|---|---|---|
| 2018-01-27 11:43:00 | By docking onto the NCP surface in this distinct orientation, Bre1 positions the Rad6 active site directly over H2B Lys123. The Spt-Ada-Gcn5 acetyltransferase (SAGA) H2B deubiquitinase module competes with Bre1 for binding to the NCP acidic patch, indicating regulatory control. Our study reveals a mechanism that ensures site-specific NCP ubiquitination and fine-tuning of opposing enzymatic activities | 27601672 |
| 2017-09-02 11:21:00 | The histone modification domain of Paf1 complex subunit Rtf1 directly stimulates H2B ubiquitylation through an interaction with Rad6. | 27840029 |
| 2017-08-26 12:26:00 | Rad6-Bre1 pathway regulates both telomere length and recombination through its role in histone H2B lysine 123 mono-ubiquitination | 28180293 |
| 2016-05-14 10:44:00 | Free ubiquitin interacts weakly with both non-canonical and canonical backside residues of Rad6 and that mutations of non-canonical residues have deleterious effects on Rad6 activity. | 26286193 |
| 2015-12-12 11:36:00 | The authors demonstrate that tombusvirus RNA replication and the mono- and bi-ubiquitination level of p33 is decreased in rad6Delta yeast. However, plasmid-based expression of the Arabidopsis Ubc2p could complement both defects in rad6Delta yeast. | 26135843 |
| Type | IDs |
|---|---|
| Synonymous | PSO8, UBC2 |
| Gene |
UniProtKB-ID:
UBC2_YEAST
UniprotKB:
P06104
UniParc:
UPI0000137959
EMBL:
K02962,
BK006941,
Z72580
EnsemblGenome:
YGL058W
KO:
sce:YGL058W
|
| Nucleutide sequences |
EMBL-CDS:
AAA34952.1,
CAA96761.1,
DAA08044.1
EnsemblGenome_TRS:
YGL058W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YGL058W
RefSeq:
NP_011457.1
|
| Others |
UniRef100:
UniRef100_P06104
UniRef90:
UniRef90_P06104
UniRef50:
UniRef50_P06104
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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