| Type | Description |
|---|---|
| Definition | stress-responsive transcription factor HSF1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-13 13:28:00 | Transient intracellular acidification regulates the core transcriptional heat shock response. | 32762843 |
| 2020-02-22 12:04:00 | Hsp70 binds Hsf1 via its canonical substrate binding domain and Hsp70 regulates Hsf1 DNA-binding activity. During heat shock, Hsp70 is out-titrated by misfolded proteins derived from ongoing translation in the cytosol. | 31552827 |
| 2019-09-21 11:51:00 | Authors show that Hsf1 phosphorylation promotes cell-to-cell variation, and this variation, rather than absolute Hsf1 activity, promotes antifungal resistance. Authors propose that Hsf1 phosphorylation enables differential tuning of the proteostasis network in individual cells, allowing populations to access a range of phenotypic states. | 29562166 |
| 2019-08-10 12:34:00 | The authors mapped a discrete Hsp70 binding site on Hsf1 to a C-terminal segment known as conserved element 2 (CE2). In vitro, CE2 binds to Hsp70 with low affinity (9 microM), in agreement with model requirements. In cells, removal of CE2 resulted in increased basal Hsf1 activity and delayed deactivation during heat shock, while tandem repeats of CE2 sped up Hsf1 deactivation. | 29393852 |
| 2018-09-22 10:07:00 | we show here that a predicted low-complexity interacting region in the disordered C-terminus of the stress response master regulator heat shock factor 1 (Hsf1) protein corresponds to a cryptic amyloid region able to self-assemble into fibrillary structures resembling those found in neurodegenerative disorders | 29734798 |
| Type | IDs |
|---|---|
| Synonymous | EXA3, MAS3 |
| Gene |
UniProtKB-ID:
HSF_YEAST
UniprotKB:
P10961
UniParc:
UPI000012CCF6
EMBL:
BK006941,
J03139,
M22040,
Z72596
EnsemblGenome:
YGL073W
KO:
sce:YGL073W
|
| Nucleutide sequences |
EMBL-CDS:
DAA08031.1,
AAA34688.1,
CAA96777.1,
AAA34689.1
EnsemblGenome_TRS:
YGL073W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YGL073W
RefSeq:
NP_011442.3
|
| Others |
UniRef100:
UniRef100_P10961
UniRef90:
UniRef90_P10961
UniRef50:
UniRef50_P10961
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
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