| Type | Description |
|---|---|
| Definition | mRNA-binding protein NAB2 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-02 12:53:00 | Dbp5 associates with RNA-bound Mex67 and Nab2 and its localization at the nuclear pore complex is sufficient for mRNP export and cell viability. | 33002012 |
| 2020-03-28 12:07:00 | The poly(A) RNA binding Zn finger ribonucleoprotein Nab2 functions to control the length of 3' poly(A) tails in Saccharomyces cerevisiae as well as contributing to the integration of the nuclear export of mature mRNA with preceding steps in the nuclear phase of the gene expression pathway. Nab2 orthologues in higher Eukaryotes have similar domain structures. [review] | 30578643 |
| 2017-11-04 11:11:00 | Binding A11G RNA induces dimerization of Zn fingers 5-7 mediated by the novel spatial arrangement of the fingers promoting each RNA chain binding two protein chains. The dimerization of Nab2 induced by RNA binding provides a basis for understanding its function in both poly(A) tail length regulation and in the compaction of mature transcripts to facilitate nuclear export. | 28180315 |
| 2017-10-28 12:53:00 | Studies provide evidence Nab2 is important for efficient RNAPIII transcription initiation in addition to its known functions in gene expression, i.e., poly(A) tail length control, mRNP biogenesis, and nuclear mRNA export. | 27049816 |
| 2017-04-20 16:24:00 | Nab2p uses its last two CCCH domains and its RGG-box to form a Nab2p/poly(A) complex of unusual topology that defines and controls mRNA poly(A) tail length by preventing 3'-end accessibility to the poly(A) polymerase | 18304944 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
NAB2_YEAST
UniprotKB:
P32505
UniParc:
UPI0000052F81
EMBL:
L08079,
Z72644,
AY723810,
L10288,
BK006941
EnsemblGenome:
YGL122C
KO:
sce:YGL122C
|
| Nucleutide sequences |
EMBL-CDS:
DAA07987.1,
AAA34820.1,
CAA96830.1,
AAA34819.1,
AAU09727.1
EnsemblGenome_TRS:
YGL122C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YGL122C
RefSeq:
NP_011393.3
|
| Others |
UniRef100:
UniRef100_P32505
UniRef90:
UniRef90_P32505
UniRef50:
UniRef50_P32505
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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