| Type | Description |
|---|---|
| Definition | anaphase promoting complex subunit DOC1 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 11:23:00 | The anaphase-promoting complex/cyclosome (APC/C) is suppressed by the small pseudosubstrate inhibitor Acm1. Acm1 D-box extension inhibits reaction processivity by perturbing the normal interaction with Doc1/Apc10. These results reveal a simple, elegant mode of pseudosubstrate inhibition that combines high-affinity activator binding with specific disruption of Doc1/Apc10 function in processive ubiquitylation. | 31562243 |
| 2015-03-07 11:54:00 | Formation of a complete APC/C-activator-substrate complex leads to a major enhancement of E2 efficiency. | 24930963 |
| 2014-02-01 10:05:00 | Regulation of APC(Cdh1) E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7. | 23670162 |
| 2010-01-21 00:00:00 | Doc1 contributes to recognition of the substrate destruction box by the anaphase-promoting complex. | 15649358 |
| Type | IDs |
|---|---|
| Synonymous | APC10 |
| Gene |
UniProtKB-ID:
APC10_YEAST
UniprotKB:
P53068
UniParc:
UPI00001D4780
EMBL:
Z72762,
BK006941,
Z49149,
Z72761
EnsemblGenome:
YGL240W
KO:
sce:YGL240W
|
| Nucleutide sequences |
EMBL-CDS:
CAA96958.1,
CAA89016.1,
DAA07879.1,
CAA96959.1
Gene_ORFName:
HRC283
EnsemblGenome_TRS:
YGL240W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YGL240W
RefSeq:
NP_011274.2
|
| Others |
UniRef100:
UniRef100_P53068
UniRef90:
UniRef90_P53068
UniRef50:
UniRef50_P53068
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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