| Type | Description |
|---|---|
| Definition | tyrosyl-DNA phosphodiesterase 1 |
| Date | Results | Publications |
|---|---|---|
| 2018-01-27 10:12:00 | We show that two genes, TDP1, a tyrosyl-DNA-phosphdiesterase, and TAF12, an RNA polymerase II TATA-box binding factor, cause CIN when overexpressed in human cells. Using SDL screens in yeast, we identified a set of genes that when deleted specifically kill cells with high levels of Tdp1 | 27551064 |
| 2010-01-21 00:00:00 | Data show that mutation of a conserved active site residue converts tyrosyl-DNA phosphodiesterase I into a DNA topoisomerase I-dependent poison. | 17707402 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
TYDP1_YEAST
UniprotKB:
P38319
UniParc:
UPI0000039A95
EMBL:
Z36092,
BK006936
EnsemblGenome:
YBR223C
KO:
sce:YBR223C
|
| Nucleutide sequences |
EMBL-CDS:
CAA85186.1,
DAA07340.1
Gene_ORFName:
YBR1520
EnsemblGenome_TRS:
YBR223C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YBR223C
RefSeq:
NP_009782.3
|
| Others |
UniRef100:
UniRef100_P38319
UniRef90:
UniRef90_P38319
UniRef50:
UniRef50_P38319
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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