| Type | Description |
|---|---|
| Definition | mitofusin |
| Date | Results | Publications |
|---|---|---|
| 2020-07-25 11:14:00 | Cdc48 did not affect the ubiquitylated but fusion-incompetent variants, indicating that Fzo1 ubiquitylation is only controlled after membrane merging. Authors present an integrated model on how mitochondrial outer membranes fuse, a critical process for their respiratory function. | 31740565 |
| 2020-05-09 12:57:00 | Physics-based oligomeric models of the yeast mitofusin Fzo1 at the molecular scale in the context of membrane docking. | 31306768 |
| 2019-08-17 10:32:00 | Here, the authors identify a new function of Cdc48 in ubiquitin-dependent regulation of mitochondrial dynamics. Cdc48 synergistically regulates the ubiquitylation status of Fzo1 via Ubp12 and Ubp2, allowing to control the balance between activation or repression of mitochondrial fusion. | 29309037 |
| 2019-06-15 12:16:00 | The predicted architecture of Fzo1 improves upon the current domain annotation, with a precise description of the helical spans linked by flexible hinges, which are likely of functional significance. Site-directed mutagenesis validates salient aspects of this model, notably, the long-distance contacts and residues participating in hinges. GDP is predicted to interact with Fzo1 via G1 and G4 motifs of the GTPase domain. | 28860650 |
| 2018-12-22 11:57:00 | The Saccharomyces cerevisiae Fzo1 and animal Mitofusin proteins are highly diverged from one another and lack strong sequence similarity. | 29212658 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
FZO1_YEAST
UniprotKB:
P38297
UniParc:
UPI000013A1FA
EMBL:
BK006936,
Z36048
EnsemblGenome:
YBR179C
KO:
sce:YBR179C
|
| Nucleutide sequences |
EMBL-CDS:
CAA85140.1,
DAA07293.1
Gene_ORFName:
YBR1241
EnsemblGenome_TRS:
YBR179C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YBR179C
RefSeq:
NP_009738.1
|
| Others |
UniRef100:
UniRef100_P38297
UniRef90:
UniRef90_P38297
UniRef50:
UniRef50_P38297
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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