| Type | Description |
|---|---|
| Definition | AAA family ATPase SEC18 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-13 12:06:00 | We also show that IPA more potently and specifically inhibits NSF/Sec18 activity than does N-ethylmaleimide, requiring the administration of only low micromolar concentrations of IPA, demonstrating that this compound could help to further elucidate SNARE-priming dynamics | 31515268 |
| 2020-06-13 11:48:00 | IPA did not interfere with PA binding to another known target or with Sec18 binding to other kinds of lipids or with other steps in the in vitro fusion assay, indicating clear specificity. | 31732684 |
| 2020-04-25 12:42:00 | SNARE-only fusion is abolished by Sec17 and Sec18. Efficient fusion with Sec17 and Sec18 requires a tripartite match between the organellar identities of the R-SNARE, the Q-SNAREs, and the SM protein/complex. Sec17 and Sec18 are not simply negative regulators; they stimulate fusion with either vacuolar SNAREs and their SM protein complex HOPS or endoplasmic reticulum/cis-Golgi SNAREs and their SM protein Sly1. | 31685636 |
| 2020-03-28 11:24:00 | When SNAREs are more disassembled, as by Sec17, Sec18, and ATP (adenosine triphosphate), HOPS is required, and GST-PX does not suffice. | 31235584 |
| 2019-05-11 11:53:00 | PA regulates Sec18 function by altering its architecture and stabilizing membrane-bound Sec18 protomers | 30617180 |
| Type | IDs |
|---|---|
| Synonymous | ANU4 |
| Gene |
UniProtKB-ID:
SEC18_YEAST
UniprotKB:
P18759
UniParc:
UPI00001355CD
EMBL:
BK006936,
AF004912,
M20662,
Z35949,
X76294
EnsemblGenome:
YBR080C
KO:
sce:YBR080C
|
| Nucleutide sequences |
EMBL-CDS:
CAA53939.1,
AAB82417.1,
AAA35031.1,
CAA85025.1,
AAA35030.1,
DAA07199.1
Gene_ORFName:
YBR0736
EnsemblGenome_TRS:
YBR080C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YBR080C
RefSeq:
NP_009636.3
|
| Others |
UniRef100:
UniRef100_P18759
UniRef90:
UniRef90_P18759
UniRef50:
UniRef50_P18759
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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