| Type | Description |
|---|---|
| Definition | Sec17p |
| Date | Results | Publications |
|---|---|---|
| 2020-04-25 12:42:00 | SNARE-only fusion is abolished by Sec17 and Sec18. Efficient fusion with Sec17 and Sec18 requires a tripartite match between the organellar identities of the R-SNARE, the Q-SNAREs, and the SM protein/complex. Sec17 and Sec18 are not simply negative regulators; they stimulate fusion with either vacuolar SNAREs and their SM protein complex HOPS or endoplasmic reticulum/cis-Golgi SNAREs and their SM protein Sly1. | 31685636 |
| 2020-03-28 11:24:00 | When SNAREs are more disassembled, as by Sec17, Sec18, and ATP (adenosine triphosphate), HOPS is required, and GST-PX does not suffice. | 31235584 |
| 2018-06-23 10:39:00 | Thus, Vps33/HOPS promotes productive SNARE assembly in the presence of otherwise inhibitory Sec17. | 28925353 |
| 2018-05-19 10:19:00 | Sec17 and Sec18 act twice in the fusion cycle, binding to trans-SNARE complexes to accelerate fusion, then hydrolyzing ATP to disassemble cis-SNARE complexes. | 28718762 |
| 2015-08-08 10:35:00 | Sec17 binds to trans-SNARE complexes, oligomerizes, and inserts apolar loops into the apposed membranes, locally disturbing the lipid bilayer and lowering the energy barrier for fusion without Sec18 | 25902545 |
| Type | IDs |
|---|---|
| Synonymous | RNS3 |
| Gene |
UniProtKB-ID:
SEC17_YEAST
UniprotKB:
P32602
UniParc:
UPI0000052F73
EMBL:
M93104,
BK006936,
Z23261,
Z35811
EnsemblGenome:
YBL050W
KO:
sce:YBL050W
|
| Nucleutide sequences |
EMBL-CDS:
CAA80796.1,
AAA35029.1,
DAA07069.1,
CAA84870.1
Gene_ORFName:
YBL0505,
YBL0517
EnsemblGenome_TRS:
YBL050W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YBL050W
RefSeq:
NP_009503.1
|
| Others |
UniRef100:
UniRef100_P32602
UniRef90:
UniRef90_P32602
UniRef50:
UniRef50_P32602
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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