| Type | Description |
|---|---|
| Definition | Esc2p |
| Date | Results | Publications |
|---|---|---|
| 2019-11-30 11:36:00 | Through molecular genetic analysis of this defined fork-stalling event, coupled with the use of a genome-wide genetic screen, we identified an important role for the SUMO-like domain protein, Esc2, in limiting genome rearrangements at a telomere. Moreover, we showed that these rearrangements are driven by the combined action of the Mph1 helicase and the homologous recombination machinery | 30838410 |
| 2017-06-10 12:02:00 | The data point to the possibility that the involvement of Esc2 in the metabolism of sister chromatid junctions is, in part, via modulation of the activity of the Mus81 complex. | 27694623 |
| 2017-01-28 10:22:00 | Reb1p indeed binds to the TFC6 promoter, and is important for proper transcription start site selection and protein expression. Interestingly, loss of Reb1p association at this site has a similar effect on the adjacent divergently transcribed ESC2 promoter, resulting in a significant increase of 5'-extended ESC2 transcripts and reduction of Esc2 protein levels. | 27601258 |
| 2016-04-23 12:13:00 | Tel1, Mre11 and Esc2 can silence a reporter gene dependent on the Sir, as well as on other repair proteins. Furthermore, these proteins aid in the localization of silenced domains to specific compartments in the nucleus. | 25631822 |
| 2016-01-16 10:06:00 | Esc2 binds stalled replication forks and counteracts the anti-recombinase Srs2 helicase via a two-faceted mechanism involving chromatin recruitment and turnover of Srs2. | 26443850 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
ESC2_YEAST
UniprotKB:
Q06340
UniParc:
UPI000006AA97
EMBL:
BK006938,
U28372
EnsemblGenome:
YDR363W
KO:
sce:YDR363W
|
| Nucleutide sequences |
EMBL-CDS:
DAA12201.1,
AAB64797.1
EnsemblGenome_TRS:
YDR363W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YDR363W
RefSeq:
NP_010650.1
|
| Others |
UniRef100:
UniRef100_Q06340
UniRef90:
UniRef90_Q06340
UniRef50:
UniRef50_Q06340
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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