| Type | Description |
|---|---|
| Definition | serine/threonine-protein kinase GCN2 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:16:00 | Global translational repression induced by iron deficiency in yeast depends on the Gcn2/eIF2alpha pathway. | 31937829 |
| 2020-05-23 10:53:00 | ln4p depletion reduces this sequestration capacity, allowing uncharged tRNAGln to interact with Gcn2 kinase. The study sheds new light on mutant aaRS disease aetiologies, and explains how aaRS sequestration of uncharged tRNAs can prevent GCN4 activation under non-starvation conditions. | 32016368 |
| 2019-01-26 12:22:00 | Ssd1 overexpression in young cells reduced translation and extended lifespan, while loss of Ssd1 reduced the translational deficit of old cells and shortened lifespan. Secondly, phosphorylation of eIF2alpha, mediated by the stress kinase Gcn2, was elevated in old cells, contributing to the global reduction in translation without detectable induction of the downstream Gcn4 transcriptional activator | 30117416 |
| 2017-07-08 11:04:00 | findings demonstrate that TORC1 is an effector of Gcn2 in amino acid signaling, hence defining a novel mechanism by which TORC1 senses amino acid starvation | 28057755 |
| 2017-06-03 11:15:00 | GCN2 is required for nitrogen catabolite repression-sensitive nuclear Gln3 localization. Gcn2 functions upstream of Ure2. | 28007891 |
| Type | IDs |
|---|---|
| Synonymous | AAS1, AAS102, NDR2 |
| Gene |
UniProtKB-ID:
GCN2_YEAST
UniprotKB:
P15442
UniParc:
UPI0000053218
EMBL:
M27082,
M20487,
BK006938,
U51030
EnsemblGenome:
YDR283C
KO:
sce:YDR283C
|
| Nucleutide sequences |
EMBL-CDS:
AAB64461.1,
AAA34881.1,
DAA12123.1,
AAA34636.1
EnsemblGenome_TRS:
YDR283C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YDR283C
RefSeq:
NP_010569.3
|
| Others |
UniRef100:
UniRef100_P15442
UniRef90:
UniRef90_P15442
UniRef50:
UniRef50_P15442
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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