| Type | Description |
|---|---|
| Definition | monothiol glutaredoxin GRX3 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:12:00 | Interactions of GMP with Human Glrx3 and with Saccharomyces cerevisiae Grx3 and Grx4 Converge in the Regulation of the Gcn2 Pathway. | 32414791 |
| 2020-07-18 10:10:00 | The conserved CDC motif in the yeast iron regulator Aft2 mediates iron-sulfur cluster exchange and protein-protein interactions with Grx3 and Bol2 | 31493153 |
| 2019-05-11 11:26:00 | Study reports the crystal structure of both the Trx and Grx domains of Grx3, which enabled to model its full-length structure with an inter-domain disulfide bond. Despite the Trx domain alone losses the typical Trx activity, it significantly augments the glutathione S-transferases activity of the Grx domain, most likely via the interdomain disulfide bond. Also, Grx3 cooperates with Fra2 to regulate the activity of Atf2. | 29524511 |
| 2018-01-13 13:32:00 | We provide new mechanistic insights into Grx3/4 regulation of Sir2 by S-deglutathionylation to increase cell resistance to stress. This finding offers news perspectives on monothiol Grxs in redox signaling, describing Sir2 as a physiological substrate regulated by S-glutathionylation. | 27085841 |
| 2017-12-23 12:59:00 | Slt2 form iron/sulphur bridged clusters with Grx3 and Grx4. | 28007574 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
GLRX3_YEAST
UniprotKB:
Q03835
UniParc:
UPI0005322FB6
EMBL:
BK006938,
Z47746
EnsemblGenome:
YDR098C
KO:
sce:YDR098C
|
| Nucleutide sequences |
EMBL-CDS:
DAA11943.2,
CAA87672.1
Gene_ORFName:
YD8557.05C
EnsemblGenome_TRS:
YDR098C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YDR098C
RefSeq:
NP_010383.4
|
| Others |
UniRef100:
UniRef100_Q03835
UniRef90:
UniRef90_Q03835
UniRef50:
UniRef50_Q03835
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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