| Type | Description |
|---|---|
| Definition | kleisin alpha |
| Date | Results | Publications |
|---|---|---|
| 2020-02-22 12:34:00 | The authors show here that Scc2 also actively maintains cohesin on chromosomes during G1 in S. cerevisiae cells. It does so by blocking a Wapl-independent release reaction that requires opening the cohesin ring at its Smc3/Scc1 interface as well as the D loop of Smc1's ATPase. | 31225797 |
| 2019-02-02 11:32:00 | We demonstrate that this conserved domain is required for DNA binding by Scc3-Scc1 in vitro, as well as for the enrichment of cohesin on chromosomes and for cell viability. These findings suggest that the Scc3-Scc1 DNA-binding interface plays a central role in the recruitment of cohesin complexes to chromosomes and therefore for cohesin to faithfully execute its functions during cell division. | 30109982 |
| 2017-05-06 10:59:00 | budding yeast Plk1, Cdc5, is pre-deposited onto cohesin engaged in cohesion on chromosome arms in G2/M phase cells. The Cdc5-cohesin association is mediated by direct interaction between the polo-box domain of Cdc5 and Scc1 phosphorylated at multiple sites in its middle region. | 27325700 |
| 2017-01-14 11:35:00 | the integrity of the Pds5-Scc1 interface is indispensable for the recruitment of Pds5 to cohesin, and that its abrogation results in loss of sister chromatid cohesion and cell viability. | 26923589 |
| 2016-07-30 11:10:00 | Study shows that cohesin's release from the DNA is mediated by disengagement of the Smc3/Scc1 interface involving interaction between the SMC ATPase heads and is inhibited by Smc3 acetylation. | 26895425 |
| Type | IDs |
|---|---|
| Synonymous | PDS3, RHC21, SCC1 |
| Gene |
UniProtKB-ID:
SCC1_YEAST
UniprotKB:
Q12158
UniParc:
UPI00000530AF
EMBL:
Z74051,
U23759,
Z48432,
Y14280,
BK006938,
Z48008
EnsemblGenome:
YDL003W
KO:
sce:YDL003W
|
| Nucleutide sequences |
EMBL-CDS:
DAA11845.1,
CAA88058.1,
CAA74657.1,
CAA88356.1,
AAB38803.1,
CAA98559.1
Gene_ORFName:
YD8119.04
EnsemblGenome_TRS:
YDL003W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YDL003W
RefSeq:
NP_010281.1
|
| Others |
UniRef100:
UniRef100_Q12158
UniRef90:
UniRef90_Q12158
UniRef50:
UniRef50_Q12158
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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Ensembl: {{protein.nucleotideEnsembl}} |
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||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
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