| Type | Description |
|---|---|
| Definition | serine/threonine/tyrosine protein kinase MPS1 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 11:21:00 | The Dynamic regulation of MPS1 catalytic activity by kinetochore-localized PP2A-B56 is thus critical for controlled MPS1 activity and timely cell cycle progression. | 31511308 |
| 2019-01-12 12:14:00 | One meiotic role of Mps1 is to stabilize connections that have been established between kinetochores and microtubles by phosphorylating Dam1. | 29237818 |
| 2017-12-09 11:15:00 | An important role for Mps1 phosphorylation in the spindle assembly checkpoint activation, beyond the direct recruitment of Mad1 and Mad2. | 27280788 |
| 2017-08-12 11:09:00 | CCT271850 is a potent, selective and orally bioavailable MPS1 kinase inhibitor. On the basis of in vivo pharmacodynamic vs efficacy relationships, we predict that more than 80% inhibition of MPS1 activity for at least 24 h is required to achieve tumour stasis or regression by CCT271850. | 28334731 |
| 2017-03-18 12:57:00 | These findings highlight MPS1 as a rational therapeutic target for medulloblastoma | 27633003 |
| Type | IDs |
|---|---|
| Synonymous | PAC8, RPK1 |
| Gene |
UniProtKB-ID:
MPS1_YEAST
UniprotKB:
P54199
UniParc:
UPI000158E67E
EMBL:
Z71781,
L08909,
BK006938,
Z74076
EnsemblGenome:
YDL028C
KO:
sce:YDL028C
|
| Nucleutide sequences |
EMBL-CDS:
AAA88731.1,
CAA98587.1,
CAA96461.1,
DAA11824.2
Gene_ORFName:
D2785
EnsemblGenome_TRS:
YDL028C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YDL028C
RefSeq:
NP_010256.2
|
| Others |
UniRef100:
UniRef100_P54199
UniRef90:
UniRef90_P54199
UniRef50:
UniRef50_P54199
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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