| Type | Description |
|---|---|
| Definition | E3 ubiquitin-protein ligase BRE1 |
| Date | Results | Publications |
|---|---|---|
| 2019-07-20 12:52:00 | Bre1 mediated-uH2B promotes DSB repair through facilitating histone eviction and subsequent loading of repair proteins | 30304473 |
| 2019-03-02 11:19:00 | Bre1 mediates the ubiquitination of histone H2B by regulating Lge1 stability | 29637554 |
| 2018-07-07 11:33:00 | Bre1's function in G1 and S phases contributes to chromatid cohesion establishment, but it is not required for cohesion maintenance in G2 phase. | 29058668 |
| 2018-01-27 11:43:00 | By docking onto the NCP surface in this distinct orientation, Bre1 positions the Rad6 active site directly over H2B Lys123. The Spt-Ada-Gcn5 acetyltransferase (SAGA) H2B deubiquitinase module competes with Bre1 for binding to the NCP acidic patch, indicating regulatory control. Our study reveals a mechanism that ensures site-specific NCP ubiquitination and fine-tuning of opposing enzymatic activities | 27601672 |
| 2017-08-26 12:26:00 | Rad6-Bre1 pathway regulates both telomere length and recombination through its role in histone H2B lysine 123 mono-ubiquitination | 28180293 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
BRE1_YEAST
UniprotKB:
Q07457
UniParc:
UPI0000069EFF
EMBL:
BK006938,
Z74122
EnsemblGenome:
YDL074C
KO:
sce:YDL074C
|
| Nucleutide sequences |
EMBL-CDS:
DAA11785.1,
CAA98640.1
EnsemblGenome_TRS:
YDL074C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YDL074C
RefSeq:
NP_010209.1
|
| Others |
UniRef100:
UniRef100_Q07457
UniRef90:
UniRef90_Q07457
UniRef50:
UniRef50_Q07457
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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