| Type | Description |
|---|---|
| Definition | translocon subunit SEC61 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:34:00 | Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62. | 33398175 |
| 2020-10-24 13:59:00 | The conserved C-terminus of Sss1p is required to maintain the endoplasmic reticulum permeability barrier. | 31848225 |
| 2019-10-26 11:43:00 | data suggest that Mpd1 binding to Sec61 is a prerequisite for CPY* ERAD and confirm a role of Sec61 in ERAD of misfolded secretory proteins. | 30682149 |
| 2019-07-27 11:06:00 | Sec63 tightly associates with Sec61 through interactions in cytosolic, transmembrane, and endoplasmic reticulum -luminal domains, prying open Sec61's lateral gate and translocation pore and thus activating the channel for substrate engagement. | 30545845 |
| 2019-03-09 12:36:00 | Substitutions replacing basic residues with acidic residues in the C-terminal tail of Sec61 had an unanticipated impact upon binding of ribosomes to the Sec61 complex. The results have identified additional cytosolic segments of the Sec61 complex important for promoting the structural transition between the closed and open conformations of the complex. | 29986881 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
SC61A_YEAST
UniprotKB:
P32915
UniParc:
UPI0000135485
EMBL:
X62340,
U19104,
BK006945,
U19103
EnsemblGenome:
YLR378C
KO:
sce:YLR378C
|
| Nucleutide sequences |
EMBL-CDS:
DAA09680.1,
AAB67581.1,
CAA44215.1,
AAB67276.1
Gene_ORFName:
L3502.5
EnsemblGenome_TRS:
YLR378C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YLR378C
RefSeq:
NP_013482.1
|
| Others |
UniRef100:
UniRef100_P32915
UniRef90:
UniRef90_P32915
UniRef50:
UniRef50_P32915
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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