| Type | Description |
|---|---|
| Definition | DNA replication initiation factor CDC45 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-22 12:19:00 | Using a Fkh1-dependent origin relocalization assay, the authors determine that execution of Dbf4-dependent kinase function, including Cdc45 loading, results in dynamic relocalization of a replication origin from the nuclear periphery to the interior in G1 phase. | 31084713 |
| 2019-12-21 10:36:00 | functional importance of Cdc45 domains | 30913274 |
| 2019-06-01 12:48:00 | Rad53 binds to forkhead-associated (FHA) interaction motifs in an unstructured loop region of Cdc45, which is phosphorylated by Rad53 itself, and this interaction is necessary for the inhibition of origin firing through Sld3. Cdc45 also recruits Rad53 to stalled replication forks, which we demonstrate is important for the response to replication stress. | 30595439 |
| 2016-01-16 11:43:00 | Data show that Dbf4-dependent kinase (DDK)-phosphoryled MCM DNA helicase complex subunit MCM2 preferentially interacts with DNA replication initiation factor CDC45. | 26305950 |
| 2015-07-04 13:42:00 | Upon extrusion of ssDNA from the central channel of Mcm2-7, Dpb11 dissociates from Mcm2-7, and Dpb11 binds to ssDNA, thereby allowing GINS to bind to Cdc45.Mcm2-7 | 25659432 |
| Type | IDs |
|---|---|
| Synonymous | SLD4 |
| Gene |
UniProtKB-ID:
CDC45_YEAST
UniprotKB:
Q08032
UniParc:
UPI00000531AC
EMBL:
U56821,
BK006945,
Z73275,
U53876,
U65790
EnsemblGenome:
YLR103C
KO:
sce:YLR103C
|
| Nucleutide sequences |
EMBL-CDS:
AAC49620.1,
AAB09053.1,
CAA97668.1,
AAB67546.1,
DAA09419.1
Gene_ORFName:
L8004.11
EnsemblGenome_TRS:
YLR103C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YLR103C
RefSeq:
NP_013204.1
|
| Others |
UniRef100:
UniRef100_Q08032
UniRef90:
UniRef90_Q08032
UniRef50:
UniRef50_Q08032
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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