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850676 COF1

850676

COF1

cofilin

protein-coding

Saccharomyces cerevisiae S288c

基因描述

Type Description
Definition cofilin

研究结论

Date Results Publications
2020-03-07 11:08:00 Cyclase-associated protein (CAP) and Cofilin synergize to processively depolymerize actin filament pointed ends at a rate 330-fold faster than spontaneous depolymerization. Single molecule imaging further reveals that hexameric CAP molecules interact with the pointed ends of Cofilin-decorated filaments for several seconds at a time, removing approximately 100 actin subunits per binding event. 31757952
2017-08-05 12:37:00 Report structural basis for noncanonical substrate recognition of cofilin-1/LIMK1 to regulation actin cytoskeleton dynamics. 27153537
2015-12-26 12:19:00 Using multi-color total internal reflection fluorescence microscopy, the study shows that Crn1 enhances Cof1-mediated severing by accelerating Cof1 binding to actin filament sides. 26299936
2013-06-08 13:03:00 Data indicate that the combined activities of cofilin and Srv2/CAP lead to enhanced filament severing and support an emerging view that actin disassembly is controlled not by cofilin alone, but by a more complex set of factors working in concert. 23135996
2012-10-13 10:25:00 Findings highlight the conserved role of cofilin and SPCA1/Pmr1 in sorting of the soluble secretory proteins at the trans-Golgi network/late Golgi membranes in eukaryotes. 22553351

名称对应

Type IDs
Gene
UniProtKB-ID: COFI_YEAST
UniprotKB: Q03048
UniParc: UPI0000110C55
EMBL: Z47973, D13230, Z73155, BK006945, Z14971, S52662
EnsemblGenome: YLL050C
KO: sce:YLL050C
Nucleutide sequences
EMBL-CDS: AAA13256.1, DAA09274.1, CAA97502.1, CAA88007.1, BAA02514.1, CAA78694.1
Gene_ORFName: L0596
EnsemblGenome_TRS: YLL050C_mRNA
Protein sequencees
EnsemblGenome_PRO: YLL050C
RefSeq: NP_013050.1
Others
UniRef100: UniRef100_Q03048
UniRef90: UniRef90_Q03048
UniRef50: UniRef50_Q03048

全选

研究热度
发表文献
研究结论
热点单位
排名 科研单位 文献
1

University of California

13
2

Brandeis University

11
3

University of Toronto

8
4

University of Minnesota-Twin Cities

3
5

Department of Chemistry and Biochemistry and Molecular Biology Institute

3
热点人员
排名 研究人员 文献
1

Bruce L Goode

11
2

D G Drubin

7
3

Emil Reisler

7
4

Charles Boone

6
5

Bryan-Joseph San Luis

5
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