| Type | Description |
|---|---|
| Definition | MutS family protein MSH4 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-25 10:41:00 | Msh4 is identified as an intrinsically unstable protein that is directly targeted for proteasomal degradation by an N-terminal degron, thereby rendering MutSgamma inactive for its crossover functions. Activation occurs by neutralizing the Msh4 degron via phosphorylation. Thus, a key meiotic pro-crossover factor is activated by attenuating its proteolysis. | 32130890 |
| 2018-06-09 11:59:00 | We closely examined two candidate genes, the chromatin remodeling gene IOC4 and the meiosis-related gene MSH4, which when knocked-out resulted in gene expression alterations affecting genes involved in cell division and chromosome organization, as well as DNA repair and recombination, respectively. | 28818866 |
| 2017-05-27 11:19:00 | The excess crossovers observed in synaptonemal complex (SC), central element-deficient mutants are Msh4, Zip1, and Zip4 dependent, clearly indicating the existence of two classes of SC proteins-a class with procrossover function(s) that are also necessary for SC assembly and a class that is not required for crossover formation but essential for SC assembly | 27184389 |
| 2014-07-26 11:58:00 | a structural rationale for the meiotic defects observed in the msh4/5 point mutations. The mutations are likely to affect stability of the Msh4/5 proteins and/or interactions with DNA. | 24244354 |
| 2011-01-01 11:14:00 | Msh4 and msh5 mutants displayed reduced crossing over in meiosis but maintained wild-type spore viability. | 20865162 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
MSH4_YEAST
UniprotKB:
P40965
UniParc:
UPI00000530F8
EMBL:
BK006940,
U13999,
D50617
EnsemblGenome:
YFL003C
KO:
sce:YFL003C
|
| Nucleutide sequences |
EMBL-CDS:
BAA09235.1,
DAA12436.1,
AAA65234.1
EnsemblGenome_TRS:
YFL003C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YFL003C
RefSeq:
NP_116652.1
|
| Others |
UniRef100:
UniRef100_P40965
UniRef90:
UniRef90_P40965
UniRef50:
UniRef50_P40965
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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