| Type | Description |
|---|---|
| Definition | SCF ubiquitin ligase complex subunit CDC4 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 11:44:00 | Study revealed that two essential Skp, Cullin, F-box (SCF) ubiquitin ligases defined by the F-box proteins Met30 and Cdc4 cooperatively regulate Cse4 (S. cerevisiae homolog of human centromere protein-A (CENP-A)) proteolysis under normal physiological conditions. Results suggest SCF-Met30/Cdc4-mediated proteolysis of Cse4 is one of the major mechanisms that prevents stable maintenance of Cse4 at non-centromeric regions. | 32032354 |
| 2018-11-17 10:43:00 | An allosteric conduit facilitates dynamic multisite substrate recognition by the SCF ubiquitin ligase. | 28045046 |
| 2017-09-23 12:32:00 | Our observations suggest that both APC(Cdh1) and SCF(Cdc4)-dependent proteolysis of Clb6 at the G1/S border are crucial for multiple cell cycle regulated events including proper expression of Clb2, the G1/S and G2/M cell cycle transitions and for proper completion of cell division at mitotic exit. | 26994663 |
| 2014-06-28 10:31:00 | an intricate coordination between Hst3 synthesis, genome-wide H3K56 deacetylation by Hst3, and cell cycle-regulated degradation of Hst3 by cyclin-dependent kinases and SCF(Cdc4). | 24648511 |
| 2013-01-05 10:55:00 | we show that Cln3 is redundantly targeted by two F-box proteins with key cell cycle-regulatory roles, Cdc4 and Grr1 | 22844257 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
CDC4_YEAST
UniprotKB:
P07834
UniParc:
UPI0000127254
EMBL:
D50617,
X05625,
Z46255,
BK006940
EnsemblGenome:
YFL009W
KO:
sce:YFL009W
|
| Nucleutide sequences |
EMBL-CDS:
CAA29113.1,
CAA86341.1,
DAA12431.1,
BAA09229.1
EnsemblGenome_TRS:
YFL009W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YFL009W
RefSeq:
NP_116585.1
|
| Others |
UniRef100:
UniRef100_P07834
UniRef90:
UniRef90_P07834
UniRef50:
UniRef50_P07834
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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