USP45 - ubiquitin specific peptidase 45-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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85015 USP45

基因描述

Type	Description
Definition	ubiquitin specific peptidase 45

研究结论

Date	Results	Publications
2020-06-06 11:12:00	Our study implicates that biallelic mutations in USP45 are associated with the occurrence of LCA. Moreover, our results indicate that USP45 is indispensable to the maintenance of photoreceptor function.	30573563
2019-11-30 10:04:00	Using mass spectrometry this study identified CCDC99 as a new target of USP45. The data showed that CCDC99 and USP45 are part of the same complex and that their interaction specifically depends on the catalytic activity of USP45.	30258100
2015-03-28 12:41:00	these results establish USP45 as a new regulator of XPF-ERCC1 crucial for efficient DNA repair	25538220

名称对应

Type	IDs
Gene	UniProtKB-ID: UBP45_HUMAN, D6RBV3_HUMAN UniprotKB: Q70EL2, D6RBV3 UniParc: UPI000003E82F, UPI0000F3BE76, UPI0000253B80, UPI0000246E86 EMBL: AL713747, AL137784, BC150648, CH471051, AL832030, BC005991, AJ583819, BC157838, AL513550 Ensembl: ENSG00000123552 KO: hsa:85015
Nucleutide sequences	EMBL-CDS: CAE47746.2, AAI50649.1, AAI57839.1, CAD89915.1, AAH05991.1, CAD91148.1, EAW48469.1 Gene_ORFName: hCG_17265 Ensembl_TRS: ENST00000327681, ENST00000500704, ENST00000472914, ENST00000329966
Protein sequencees	Ensembl_PRO: ENSP00000424372, ENSP00000333376, ENSP00000423993, ENSP00000330540 RefSeq: NP_001332956.1, NP_001332954.1, XP_016866871.1, NP_001332955.1, XP_016866870.1, NP_001332957.1, XP_016866875.1, NP_001332952.1, NP_001332962.1, NP_001332958.1, NP_001332959.1, NP_116318.2, NP_001332953.1, XP_024302342.1, NP_001073950.1, XP_005267227.1, NP_001332950.1, XP_016866874.1, NP_001332951.1
Others	UniRef100: UniRef100_Q70EL2, UniRef100_D6RBV3 UniRef90: UniRef90_Q70EL2-2, UniRef90_Q70EL2 UniRef50: UniRef50_Q70EL2-2, UniRef50_Q70EL2 UniGene: Hs.143410 CCDS: CCDS34501.1, CCDS87419.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
30573563	Biallelic mutations in USP45, encoding a deubiquitinating enzyme, are associated with Leber congenital amaurosis. J. Med. Genet. Zhen Yi , Jiamin Ouyang , Wenmin Sun , Xueshan Xiao , Shiqiang Li , Xiaoyun Jia , Panfeng Wang , Qingjiong Zhang	2019-05-01	-
30021884	Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Mol Cell Proteomics Domenico Fasci , Hugo van Ingen , Richard A Scheltema , Albert J R Heck	2018-10-01	-
30258100	USP45 and Spindly are part of the same complex implicated in cell migration. Sci Rep Claudia Conte , Eric R Griffis , Ian Hickson , Ana B Perez-Oliva	2018-09-26	-
29576527	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability. Mol Cell Dominika Kwasna , Syed Arif Abdul Rehman , Jayaprakash Natarajan , Stephen Matthews , Ross Madden , Virginia De Cesare , Simone Weidlich , Satpal Virdee , Ivan Ahel , Ian Gibbs-Seymour , Yogesh Kulathu	2018-04-05	-
26496610	A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell Marco Y Hein , Nina C Hubner , Ina Poser , JÃ¼rgen Cox , Nagarjuna Nagaraj , Yusuke Toyoda , Igor A Gak , Ina Weisswange , JÃ¶rg Mansfeld , Frank Buchholz , Anthony A Hyman , Matthias Mann	2015-10-22	Cep85l, Rcc1, Zbtb48, Bsdc1, Kifc1, Ccp110, Ints4, Slc6a8, Cenpi, Nup107, Xpo1, Fbxw11, Tubg1, Csnk1d, Bap1, Ptpn23, Tecpr2, Slain1, Ankrd28, Prkaa1, Espl1, Gbf1, Cdc20, Cenpf, Trip11, Mbd5, Kif22, Dut, Srsf1, Actb, Spred2, Akt2, Mta1, Tgs1, Pip4k2c, Ankfy1, Apc, Ar, Rhoa, Atp2a2, Atp5a1, Atp7a, Cep131, Bach1, Bcl7c, Bmpr1a, Brca1, Bub1, Bub1b, C1qbp, Anxa2, Calu, Cbx1, Cbx4, Cct2, Cct3, Cct4, Cct7, Cct8, Cd2ap, Cdk1, Cdc37, Cdh1, Chek1, Cit, Copa, Crebbp, Cry1, Csk, Smc3, Dctn1, Ddb1, Cdk2ap1, Mapre1, Ect2, Eef1a1, Eif3a, Mark2, Evpl, Ewsr1, Wdr5, Dclre1b, Fbl, Fgfr1, Flot1, Flot2, B4galt1, Gnb1, Gspt1, Hdac6, Herc2, Hsf1, Hsph1, Elavl1, Id2, Cyr61, Cep250, Insr, Eif3e
25538220	USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses. EMBO J. Ana B Perez-Oliva , Christophe Lachaud , Piotr Szyniarowski , Ivan MuÃ±oz , Thomas Macartney , Ian Hickson , John Rouse , Dario R Alessi	2015-02-03	-
19615732	Defining the human deubiquitinating enzyme interaction landscape. Cell Mathew E Sowa , Eric J Bennett , Steven P Gygi , J Wade Harper	2009-07-23	-
15761153	High-throughput mapping of a dynamic signaling network in mammalian cells. Science Miriam Barrios-Rodiles , Kevin R Brown , Barish Ozdamar , Rohit Bose , Zhong Liu , Robert S Donovan , Fukiko Shinjo , Yongmei Liu , Joanna Dembowy , Ian W Taylor , Valbona Luga , Natasa Przulj , Mark Robinson , Harukazu Suzuki , Yoshihide Hayashizaki , Igor Jurisica , Jeffrey L Wrana	2005-03-11	-
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. Daniela S Gerhard , Lukas Wagner , Elise A Feingold , Carolyn M Shenmen , Lynette H Grouse , Greg Schuler , Steven L Klein , Susan Old , Rebekah Rasooly , Peter Good , Mark Guyer , Allison M Peck , Jeffery G Derge , David Lipman , Francis S Collins , Wonhee Jang , Steven Sherry , Mike Feolo , Leonie Misquitta , Eduardo Lee , Kirill Rotmistrovsky , Susan F Greenhut , Carl F Schaefer , Kenneth Buetow , Tom I Bonner , David Haussler , Jim Kent , Mark Kiekhaus , Terry Furey , Michael Brent , Christa Prange , Kirsten Schreiber , Nicole Shapiro , Narayan K Bhat , Ralph F Hopkins , Florence Hsie , Tom Driscoll , M Bento Soares , Tom L Casavant , Todd E Scheetz , Michael J Brown-stein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Yulan Piao , Dawood B Dudekula , Minoru S H Ko , Koichi Kawakami , Yutaka Suzuki , Sumio Sugano , C E Gruber , M R Smith , Blake Simmons , Troy Moore , Richard Waterman , Stephen L Johnson , Yijun Ruan , Chia Lin Wei , S Mathavan , Preethi H Gunaratne , Jiaqian Wu , Angela M Garcia , Stephen W Hulyk , Edwin Fuh , Ye Yuan , Anna Sneed , Carla Kowis , Anne Hodgson , Donna M Muzny , John McPherson , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madari , Alice C Young , Keith D Wetherby , Steven J Granite , Peggy N Kwong , Charles P Brinkley , Russell L Pearson , Gerard G Bouffard , Robert W Blakesly , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Malachi Griffith , Obi L Griffith , Martin I Krzywinski , Nancy Liao , Ryan Morin , Ryan Morrin , Diana Palmquist , Anca S Petrescu , Ursula Skalska , Duane E Smailus , Jeff M Stott , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Robert A Holt , Agnes Baross , Marco A Marra , Sandra Clifton , Kathryn A Makowski , Stephanie Bosak , Joel Malek , MGC Project Team	2004-10-01	Ldlrap1, Dnajc3, Rnaset2a, Btnl1, Isg15, Cyp3a41b, Ly6c2, Ccl21b, Eif3j2, Mup18, Lrrc19, Rcc1, 1700047I17Rik2, Pcsk9, Adat3, Tdrd7, Sco2, Gpr153, Pafah2, Gm44504, H6pd, Adprhl2, Gpn2, Rusc2, Stx12, Ppp1r8, Smpdl3b, Fam46b, Bsdc1, Slc44a1, Zfand2a, Rubcn, Kifc1, Pifo, C030017K20Rik, Cbarp, Rpl5, Micalcl, Atg14, Lrrc8c, Noc4l, Nsun5, Psph, Trrap, Mapre3, Ube3c, Tbc1d14, Hscb, Tyw1, Emilin1, Rab28, Pot1a, Parp11, Tada3, Tra2a, Brk1, Fbxl14, Phrf1, Plekha1, Gm21975, Ric8a, Mob2, Prkd2, Ccp110, Vrk3, Grwd1, Nlrp6, Trim68, Psip1, Spred3, Faap24, Ints4, Rrp8, Unc45a, Igflr1, Sf3b3, D8Ertd738e, Usb1, Champ1, Smim19, Exoc8, Gadd45gip1, Phkb, Dohh, Fam192a, Enkd1, Taf5l, Zdhhc7, Snapc2, Ak6, Gpat4, Dcun1d2, Ankrd10, Cog4, Hinfp, Lars2, Xylb, Imp3, Cmtm7
14715245	Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. Biochem. Biophys. Res. Commun. VÃctor Quesada , Araceli DÃaz-Perales , Ana GutiÃ©rrez-FernÃ¡ndez , Cecilia Garabaya , Santiago Cal , Carlos LÃ³pez-OtÃn	2004-01-30	-

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