| Type | Description |
|---|---|
| Definition | leucine rich repeat and Ig domain containing 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-06 10:27:00 | LINGO1 is a regulator of BK channels. | 31932443 |
| 2019-07-06 11:00:00 | LINGO1 might be a positive primary glioblastoma prognostic gene and C7orf31 and VEGFA might be negative prognosticators. | 30064229 |
| 2018-12-22 10:45:00 | We identified homozygous missense variants in LINGO1, p.(Arg290His) in family F162 and p.(Tyr288Cys) in family PKMR65. Both variants were predicted to be pathogenic, and segregated with the phenotype in the respective families. Molecular modeling of LINGO1 suggests that both variants interfere with the glycosylation of the protein. | 28837161 |
| 2016-09-10 11:59:00 | LINGO1 rs11856808 plays a protective role by decreasing the risk for PD, but not for MSA, in Chinese population. | 26254004 |
| 2016-08-20 10:08:00 | LINGO1 protein acts as a gateway protein internalizing into the tumor cells when engaged by antibody and can carry antibody conjugated with drugs to kill Ewing sarcoma cells. | 26979953 |
| Type | IDs |
|---|---|
| Synonymous | LERN1, LRRN6A, MRT64, UNQ201 |
| Gene |
UniProtKB-ID:
LIGO1_HUMAN
UniprotKB:
Q96FE5
UniParc:
UPI00000377A0,
UPI000004C7CE
EMBL:
AK027500,
AY324322,
AY324323,
AK291363,
BC011057,
AL834260,
AY324320,
AY358284,
BC068558,
CH471136
Ensembl:
ENSG00000169783
KO:
hsa:84894
|
| Nucleutide sequences |
EMBL-CDS:
EAW99196.1,
AAQ88651.1,
AAQ97217.1,
EAW99198.1,
CAD38935.1,
BAF84052.1,
AAH68558.1,
EAW99197.1,
AAH11057.2,
AAQ97218.1,
EAW99195.1,
AAQ97216.1,
BAB55157.1
Gene_ORFName:
UNQ201/PRO227
Ensembl_TRS:
ENST00000355300,
ENST00000561030
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000453853,
ENSP00000347451
RefSeq:
NP_001288115.1,
XP_024305859.1,
NP_001288121.1,
NP_001288129.1,
XP_011520420.1,
NP_001288123.1,
NP_001288120.1,
NP_001288124.1,
NP_116197.4,
XP_016878171.1,
NP_001288128.1,
NP_001288116.1,
NP_001288126.1,
NP_001288127.1,
NP_001288118.1
|
| Others |
UniRef100:
UniRef100_Q96FE5
UniRef90:
UniRef90_Q96FE5
UniRef50:
UniRef50_Q96FE5
UniGene:
Hs.656765,
Hs.745412
CCDS:
CCDS73766.1,
CCDS45313.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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