| Type | Description |
|---|---|
| Definition | signal peptide peptidase like 2A |
| Date | Results | Publications |
|---|---|---|
| 2020-05-09 10:25:00 | SPPL2a/b negatively regulates LOX-1 signaling and atherosclerosis. | 30819724 |
| 2019-05-25 10:52:00 | inherited SPPL2a deficiency in humans underlies mycobacterial disease by decreasing the numbers of dendritic cells and impairing IFN-gamma production by mycobacterium-specific memory TH1* cells | 30127434 |
| 2017-05-20 14:31:00 | Study propose that elements within the transmembrane segment and the luminal juxtamembrane domain facilitate intramembrane proteolysis of CD74 by SPPL2a. | 26987812 |
| 2014-12-20 12:04:00 | In human B cells, SPPL2a is indispensable for turnover of CD74 N-terminal fragment. A human 15q21.2 microdeletion leads to loss of SPPL2a transcript and protein. | 25035924 |
| 2014-10-04 10:58:00 | Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a). | 24872421 |
| Type | IDs |
|---|---|
| Synonymous | IMP3, PSL2 |
| Gene |
UniProtKB-ID:
SPP2A_HUMAN
UniprotKB:
Q8TCT8
UniParc:
UPI0000013591
EMBL:
AK315651,
BC025740,
AK027446,
AY169314,
AJ420896,
AK075454,
CH471082,
AJ345028
Ensembl:
ENSG00000138600
KO:
hsa:84888
|
| Nucleutide sequences |
EMBL-CDS:
CAD13133.1,
AAH25740.1,
EAW77410.1,
BAC11630.1,
BAG38017.1,
CAC87789.1,
AAO12539.1,
BAB55117.1
Gene_ORFName:
PSEC0147
Ensembl_TRS:
ENST00000261854
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000261854
RefSeq:
NP_116191.2,
XP_016878169.1,
XP_005254779.1,
XP_016878170.1
|
| Others |
UniRef100:
UniRef100_Q8TCT8
UniRef90:
UniRef90_Q8TCT8
UniRef50:
UniRef50_Q8TCT8
UniGene:
Hs.401537
CCDS:
CCDS10138.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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