| Type | Description |
|---|---|
| Definition | protein tyrosine phosphatase non-receptor type 5 |
| Date | Results | Publications |
|---|---|---|
| 2020-03-14 10:23:00 | that STEP61 is the molecular brake that is lost following KCC2-dependent disinhibition and that the decrease in STEP61 activity drives the potentiation of excitatory GluN2B NMDAR responses in rodent and human models of pathological pain | 31135041 |
| 2018-05-19 12:21:00 | validated the functional importance of an identified interaction network by characterizing a distinct novel interaction between PTPN5 and Mob1a. | 28675297 |
| 2018-03-10 11:57:00 | This current study demonstrated that spinal STEP61 regulated LTP of C fiber-evoked field potentials, one of the extensively studied cellular models of central sensitization. | 28389375 |
| 2018-02-03 11:11:00 | a dual role for PSD-95 in stabilizing synaptic NMDARs by binding directly to GluN2B but also by promoting synaptic exclusion and degradation of the negative regulator STEP61. | 27457929 |
| 2017-11-11 12:45:00 | STEP is involved in the mechanism of depressive disorders and it is a promising molecular target for atypical antidepressant drugs of new generation. (Review) | 28699511 |
| Type | IDs |
|---|---|
| Synonymous | PTPSTEP, STEP, STEP61 |
| Gene |
UniProtKB-ID:
PTN5_HUMAN,
Q86TL3_HUMAN,
B7Z2F8_HUMAN
UniprotKB:
P54829,
Q86TL3,
B7Z2F8
UniParc:
UPI00004A2823,
UPI0001914C7D,
UPI000000DB7E,
UPI00000473F7,
UPI00001AE663
EMBL:
AK127312,
AK316270,
AK295604,
U27831,
AL832541,
AK294673,
BC064807,
CH471064,
AC103974,
BC046435,
AK090923
Ensembl:
ENSG00000110786
KO:
hsa:84867
|
| Nucleutide sequences |
EMBL-CDS:
BAC03548.1,
AAA87555.1,
EAW68363.1,
BAH14641.1,
CAD38632.2,
EAW68367.1,
EAW68365.1,
BAG54479.1,
AAH64807.1,
BAH12122.1,
AAH46435.1,
BAH11844.1
Ensembl_TRS:
ENST00000358540,
ENST00000396168,
ENST00000396170
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000379473,
ENSP00000379471,
ENSP00000351342
RefSeq:
XP_016873927.1,
XP_016873926.1,
XP_016873923.1,
XP_016873929.1,
NP_001035059.1,
XP_011518713.1,
XP_016873928.1,
NP_008837.1,
XP_016873925.1,
NP_001265167.1,
NP_001265168.1,
NP_116170.3,
XP_016873924.1,
XP_016873930.1,
NP_001265165.1
|
| Others |
UniRef100:
UniRef100_P54829,
UniRef100_B7Z2F8
UniRef90:
UniRef90_P54829,
UniRef90_B7Z2F8
UniRef50:
UniRef50_A0A2K5XJV1,
UniRef50_P54829
UniGene:
Hs.79092
CCDS:
CCDS60746.1,
CCDS7845.1,
CCDS41626.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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