| Type | Description |
|---|---|
| Definition | kelch like family member 22 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-09 13:33:00 | KLHL22 maintains PD-1 homeostasis and prevents excessive T cell suppression. | 33109719 |
| 2020-12-19 13:38:00 | KLHL22 promotes malignant melanoma growth in vitro and in vivo by activating the PI3K/Akt/mTOR signaling pathway. | 32484697 |
| 2018-11-24 11:21:00 | KLHL22 plays a conserved role to mediate the activation of mTORC1 and downstream events; depletion of KLHL22 in breast cancer cells suppresses tumour growth in nude mice; therefore, pharmacological interventions targeting KLHL22 may have therapeutic potential for the treatment of breast cancer and age-related diseases | 29769719 |
| 2014-03-08 10:43:00 | CUL3/KLHL22 may contact two distinct motifs within PLK1 protein, consistent with the bivalent mode of substrate targeting. | 24067371 |
| Type | IDs |
|---|---|
| Synonymous | KELCHL |
| Gene |
UniProtKB-ID:
KLH22_HUMAN
UniprotKB:
Q53GT1
UniParc:
UPI0001914CA3,
UPI0000072F37
EMBL:
CH471176,
AC007731,
AK290669,
AK027266,
AK222850,
BC015923,
AK294682,
CR456352
Ensembl:
ENSG00000099910
KO:
hsa:84861
|
| Nucleutide sequences |
EMBL-CDS:
BAD96570.1,
EAX02962.1,
CAG30238.1,
BAB55007.1,
BAF83358.1,
BAH11847.1,
AAH15923.1,
EAX02963.1,
EAX02961.1
Ensembl_TRS:
ENST00000328879
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000331682
RefSeq:
XP_016884514.1,
XP_016884508.1,
XP_016884510.1,
XP_016884511.1,
XP_016884509.1,
NP_116164.2,
XP_016884512.1,
XP_016884513.1,
XP_016884507.1
|
| Others |
UniRef100:
UniRef100_Q53GT1
UniRef90:
UniRef90_Q53GT1
UniRef50:
UniRef50_Q53GT1
UniGene:
Hs.517419
CCDS:
CCDS13780.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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