| Type | Description |
|---|---|
| Definition | CDC42 binding protein kinase alpha |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:25:00 | The Na+, K+-ATPase beta1 subunit regulates epithelial tight junctions via MRCKalpha. | 33507884 |
| 2021-02-13 13:26:00 | Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma. | 32071169 |
| 2018-11-03 10:50:00 | The authors describe the discovery of MRCKalpha as a downstream effector of apoptosis and trigger of epithelial extrusion. By describing this novel role of MRCKalpha during apoptosis, the authors cast light on the complex actomyosin cytoskeleton dynamics in the process of epithelial cell extrusion and, likely, in the homeostatic maintenance of tissues in multicellular organisms. | 29162624 |
| 2018-09-22 12:00:00 | Cdc42BPA and Cdc42 signaling are important for colon cancer invasion, and Cdc42BPA has potential implications for colon cancer prognosis and treatment. | 29072916 |
| 2018-07-21 11:57:00 | Silencing of CDC42BPA expression partially reduces miR29a3p inhibitor-induced migration and invasion of SW4807 cells | 29039592 |
| Type | IDs |
|---|---|
| Synonymous | MRCK, MRCKA, PK428 |
| Gene |
UniProtKB-ID:
MRCKA_HUMAN
UniprotKB:
Q5VT25
UniParc:
UPI00005D3C33,
UPI000019097D,
UPI000019097C,
UPI00017BE78A,
UPI00005D3C32,
UPI0000458A1E
EMBL:
U59305,
AL627308,
AB208968,
AJ518975,
AB007920,
AL353689,
AL451047,
CR933723,
AJ518976
Ensembl:
ENSG00000143776
KO:
hsa:8476
|
| Nucleutide sequences |
EMBL-CDS:
CAI19110.1,
CAD57746.1,
AAB37126.1,
CAH71337.1,
CAD57745.1,
CAI19113.1,
CAI19109.1,
CAH71184.1,
CAI19108.1,
BAA32296.2,
CAH71338.1,
BAD92205.1,
CAH71183.1,
CAH71336.1,
CAI46252.1,
CAH71185.1
Ensembl_TRS:
ENST00000334218,
ENST00000366769,
ENST00000366767
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000335341,
ENSP00000355729,
ENSP00000355731
RefSeq:
XP_016858070.1,
NP_055641.3,
XP_006711898.1,
NP_001374479.1,
XP_016858068.1,
XP_005273374.1,
XP_016858071.1,
XP_005273379.1,
XP_016858069.1,
XP_005273378.1,
NP_001352939.1,
NP_003598.2,
NP_001352940.1,
XP_011542610.1,
XP_016858067.1,
XP_011542609.1,
XP_005273375.1,
NP_001352948.1,
XP_005273377.1,
XP_011542611.1,
XP_006711897.1
|
| Others |
UniRef100:
UniRef100_Q5VT25
UniRef90:
UniRef90_Q5VT25
UniRef50:
UniRef50_Q5VT25
UniGene:
Hs.35433
CCDS:
CCDS1558.1,
CCDS1559.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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