| Type | Description |
|---|---|
| Definition | protein phosphatase 1 regulatory subunit 9B |
| Date | Results | Publications |
|---|---|---|
| 2018-03-31 10:55:00 | Study determined that spinophilin binding to neurofilament medium required overexpression of the catalytic subunit of protein kinase A and was decreased by cyclin-dependent protein kinase 5. | 28634551 |
| 2017-12-02 11:04:00 | Clinical onset of AD is marked by the loss of PreC spinophilin-ir dendritic spines that is related to Abeta pathology and may contribute to cognitive symptoms early in the disease. | 28259365 |
| 2017-11-26 01:39:00 | The increased cancer stem cells-like properties induced by the downregulation of Spn might account for the increased malignant phenotype observed in Spn-null breast tumors. | 26387546 |
| 2017-11-18 12:25:00 | homo-oligomerization of neurabin is required for stabilizing RGS4 on the plasma membrane to attenuate A1R signaling | 28954816 |
| 2017-08-05 12:49:00 | Data identify Spn as a critical adhesion and signaling protein that is essential for modulating glioblastoma cell invasion in the brain microenvironment. Spn suppresses brain tumor cell invasion, in part, via control of Rac1 GTPase activities and invadopodia disassembly. Its C-terminus binds directly to the beta 8 integrin cytoplasmic tail. | 27655131 |
| Type | IDs |
|---|---|
| Synonymous | PPP1R6, PPP1R9, SPINO, Spn |
| Gene |
UniProtKB-ID:
NEB2_HUMAN
UniprotKB:
Q96SB3
UniParc:
UPI00005AE42D
EMBL:
CH471109,
KF495721,
AJ401189,
ABBA01041227,
AL713642,
AC002401
Ensembl:
ENSG00000108819
KO:
hsa:84687
|
| Nucleutide sequences |
EMBL-CDS:
CAD28455.2,
EAW94637.1,
EAW94638.1,
CAC37685.1
Ensembl_TRS:
ENST00000612501
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000478767
RefSeq:
NP_115984.3
|
| Others |
UniRef100:
UniRef100_Q96SB3
UniRef90:
UniRef90_O35274
UniRef50:
UniRef50_O35274
UniGene:
Hs.514323
CCDS:
CCDS74102.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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