| Type | Description |
|---|---|
| Definition | cytochrome c oxidase subunit 4I2 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-13 13:22:00 | Acute O2 sensing through HIF2alpha-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors. | 31848220 |
| 2017-09-16 13:07:00 | Cox4i2 is essential for acute but not chronic pulmonary oxygen sensing by triggering mitochondrial hyperpolarization. | 28620066 |
| 2015-09-12 11:08:00 | Data (including data from cells of transgenic mouse embryos) suggest Hif1a (hypoxia inducible factor 1 alpha subunit) up-regulates transcription of heart/muscle isoform Cox7a1 under hypoxia; hypoxic induction of isoform Cox4i2 is HIF1a-independent. | 26030260 |
| 2012-12-29 11:40:00 | propose a model in which reduced tissue ATP levels explain protection from airway hyperresponsiveness, i.e., absence of COX4i2 leads to reduced lung COX activity and ATP levels, which results in impaired airway constriction | 22730437 |
| 2010-01-21 00:00:00 | the presence of the COX isoform IV-2 suppresses the sensitivity of COX to its allosteric regulator ATP and overrules the regulation of COX by the cellular energy level | 16981895 |
| Type | IDs |
|---|---|
| Synonymous | Cox4b, CoxIV-2 |
| Gene |
UniProtKB-ID:
COX42_MOUSE
UniprotKB:
Q91W29
UniParc:
UPI000002115E
EMBL:
BC049623,
AF271382
Ensembl:
ENSMUSG00000009876
KO:
mmu:84682
|
| Nucleutide sequences |
EMBL-CDS:
AAH49623.1,
AAK49433.1
Ensembl_TRS:
ENSMUST00000109821,
ENSMUST00000010020
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000105446,
ENSMUSP00000010020
RefSeq:
NP_444321.1
|
| Others |
UniRef100:
UniRef100_Q91W29
UniRef90:
UniRef90_Q91W29
UniRef50:
UniRef50_Q96KJ9
UniGene:
Mm.196668
CCDS:
CCDS16898.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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