| Type | Description |
|---|---|
| Definition | tripartite motif containing 63 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:25:00 | Doxorubicin induces cardiomyocyte apoptosis and atrophy through cyclin-dependent kinase 2-mediated activation of forkhead box O1. | 32075913 |
| 2020-07-25 10:31:00 | MuRF1 turned out to be also a target for a new post-translational modification arbitrated by conjugation of SUMO1 and it is mediated by the SUMO ligases E2 UBC9 and the E3 PIASgamma/4. SUMOylation takes place at lysine 238 localized at the second coiled-coil protein domain that is required for efficient substrate interaction for polyubiquitination. | 29868881 |
| 2020-06-20 12:46:00 | Using a combination of electron paramagnetic resonance, on spin-labeled protein, and disulfide crosslinking, the study shows that TRIM63 follows the structural conservation of the TRIM dimerization domain, observed in other proteins. the COS-box motif folds back onto the dimerization coiled-coil motif, predictably forming a four-helical bundle at the center of the protein and emulating the architecture of canonical TRIMs. | 31125568 |
| 2020-05-30 13:50:00 | an impaired interaction between titin and MURF1 as a novel mechanism underlying the pathogenesis ofHypertrophic cardiomyopathy (HCM). | 31628103 |
| 2020-02-29 10:47:00 | Our study revealed that TRIM63, acting as an oncogene, is involved in breast cancer progression by activating the Wnt/beta-catenin signaling pathway | 31399258 |
| Type | IDs |
|---|---|
| Synonymous | IRF, MURF1, MURF2, RNF28, SMRZ |
| Gene |
UniProtKB-ID:
TRI63_HUMAN
UniprotKB:
Q969Q1
UniParc:
UPI00017A7764,
UPI00000437F6
EMBL:
AK297820,
AF353673,
AJ276484,
AL391650,
AF361946,
BC080529,
AJ291713,
AK056942
Ensembl:
ENSG00000158022
KO:
hsa:84676
|
| Nucleutide sequences |
EMBL-CDS:
AAH80529.1,
CAC33173.1,
BAB71318.1,
AAK39519.1,
AAK52497.1,
CAC81706.1,
BAG60157.1
Ensembl_TRS:
ENST00000374272
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000363390
RefSeq:
XP_016858048.1,
NP_115977.2
|
| Others |
UniRef100:
UniRef100_Q969Q1
UniRef90:
UniRef90_Q969Q1
UniRef50:
UniRef50_Q969Q1
UniGene:
Hs.279709
CCDS:
CCDS273.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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