| Type | Description |
|---|---|
| Definition | diacylglycerol O-acyltransferase 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-01-18 11:48:00 | These data suggest that Dgat2 is an important regulator of HCC cell proliferation. | 31078041 |
| 2019-08-03 10:45:00 | A binding assay utilizing (125)I-labeled imidazopyridine demonstrated that the level of imidazopyridine binding to DGAT2 mutant enzymes, H161A and H163A, dramatically decreased to 11-17% of that of the wild-type enzyme, indicating that these residues are critical for imidazopyridines to bind to DGAT2. | 30422629 |
| 2018-12-01 11:38:00 | DGAT2 contains a C-terminal signal sequence that interacts with lipid droplets. | 29902571 |
| 2018-08-25 10:41:00 | Study identified a large cohort of patients with congenital diarrheal disorders with mutations in DGAT1 that reduced expression of its product; dermal fibroblasts and intestinal organoids derived from these patients had altered lipid metabolism and were susceptible to lipid-induced cell death. Expression of full-length wildtype DGAT1 or DGAT2 restored normal lipid metabolism in these cells. | 29604290 |
| 2017-09-30 11:48:00 | We first report loss-of-function mutations in DGAT2 and FAAH in one obese subject, which may interact with each other to affect the adiposity penetrance, providing a model of genetic interaction associated with human obesity. | 28243972 |
| Type | IDs |
|---|---|
| Synonymous | ARAT, GS1999FULL, HMFN1045 |
| Gene |
UniProtKB-ID:
DGAT2_HUMAN
UniprotKB:
Q96PD7
UniParc:
UPI00004DCB28,
UPI0000048F05
EMBL:
AL834287,
CR749377,
AB073384,
AB048286,
AY358532,
AP001922,
BC015234,
AF384161,
AY780647
Ensembl:
ENSG00000062282
KO:
hsa:84649
|
| Nucleutide sequences |
EMBL-CDS:
BAB40641.2,
CAH18230.1,
AAQ88896.1,
CAD38961.1,
BAD38635.1,
AAV35727.1,
AAH15234.1,
AAK84176.2
Gene_ORFName:
HMFN1045,
UNQ738/PRO1433
Ensembl_TRS:
ENST00000376262,
ENST00000228027
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000365438,
ENSP00000228027
RefSeq:
XP_011543606.1,
NP_001240820.1,
NP_115953.2
|
| Others |
UniRef100:
UniRef100_Q96PD7
UniRef90:
UniRef90_Q96PD7
UniRef50:
UniRef50_Q9DCV3
UniGene:
Hs.129798
CCDS:
CCDS58162.1,
CCDS31642.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员