| Type | Description |
|---|---|
| Definition | tau tubulin kinase 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-13 18:51:00 | miR-219-5p inhibits tau phosphorylation by targeting TTBK1 and GSK-3beta in Alzheimer's disease. | 30556160 |
| 2018-11-10 11:26:00 | Our findings suggest a possible etiology for the two most common frontotemporal lobar degeneration subtypes through a TTBK1/2 activation driven mechanism of neurodegeneration | 29409526 |
| 2016-01-30 11:43:00 | TTBK1/2 kinases may represent attractive targets for therapeutic intervention for TDP-43 proteinopathies such as Amyotrophic lateral sclerosis and Frontotemporal lobar degeneration-TDP. | 25473830 |
| 2014-11-22 11:14:00 | X-ray diffraction data were collected and the structure of TTBK1 was determined by molecular replacement both as an apo structure and in complex with a kinase inhibitor | 24637750 |
| 2014-02-01 10:13:00 | The study suggested that a role for TTBK1 in pre-tangle formation prior to the formation of fibrillar tau and strengthen the idea that tau is phosphorylated at Ser422 at an early/intermediate stage in NFT formation. | 23088643 |
| Type | IDs |
|---|---|
| Synonymous | BDTK |
| Gene |
UniProtKB-ID:
TTBK1_HUMAN
UniprotKB:
Q5TCY1
UniParc:
UPI000041512B,
UPI0000E5AD61
EMBL:
BC036764,
AL133375,
AK131217,
AB218664,
AB058758
Ensembl:
ENSG00000146216
KO:
hsa:84630
|
| Nucleutide sequences |
EMBL-CDS:
BAE78660.1,
AAH36764.1,
BAD18405.1,
BAB47484.1
Ensembl_TRS:
ENST00000259750
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000259750
RefSeq:
XP_016866856.1,
XP_016866855.1,
XP_011513249.1,
NP_115927.1,
XP_016866853.1,
XP_016866857.1,
XP_011513250.1,
XP_016866854.1
|
| Others |
UniRef100:
UniRef100_Q5TCY1
UniRef90:
UniRef90_Q5TCY1
UniRef50:
UniRef50_Q5TCY1
UniGene:
Hs.485436
CCDS:
CCDS34455.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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