| Type | Description |
|---|---|
| Definition | protein interacting with PRKCA 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-23 12:56:00 | multivalent protein-protein and protein-lipid interactions provide critical avidity for the strong binding between the PDZ domain scaffold proteins, PICK1 and PSD-95, and their cognate transmembrane binding partners | 30605082 |
| 2019-07-20 10:13:00 | Study shows that oxygen and glucose deprivation (OGD) causes endocytosis, lysosomal targeting and consequent degradation of GluA2- and GluA3-containing AMPARs, and that PICK1 is required for both OGD-induced GluA2 endocytosis and lysosomal sorting. GluA1-containing AMPARs resist OGD-induced endocytosis and PICK1 binding to the endocytic adaptor AP2 is enhanced by OGD in hippocampal, but not cortical neurons. | 28951554 |
| 2018-06-16 12:05:00 | study found that both GluA2 and PICK1 were down-regulated in kainate-treated rats for as long as eight weeks after induction of epilepsy; statistical analysis indicates that the functional role of PIC 1 in studied material is to increase GluA2 concentrations in the cells | 28888867 |
| 2017-11-11 12:55:00 | Results suggest that the interacting proteins PICK1 and N-ethylmaleimide sensitive fusion protein act as regulators of presynaptic GluA2-containing AMPAR trafficking between the active zone and a vesicle pool that may provide the basis of presynaptic components of synaptic plasticity. | 28057533 |
| 2017-10-07 12:31:00 | PICK1 is a cargo-specific endocytic accessory protein required for efficient, activity-dependent AMPAR endocytosis. | 28855251 |
| Type | IDs |
|---|---|
| Synonymous | Prkcabp |
| Gene |
UniProtKB-ID:
PICK1_RAT
UniprotKB:
Q9EP80
UniParc:
UPI0000003C14
EMBL:
AF373289,
AF327562,
AJ240083,
AF542094
KO:
rno:84591
|
| Nucleutide sequences |
EMBL-CDS:
CAC17808.2,
AAO49507.1,
AAK54603.1,
AAG48152.1
|
| Protein sequencees |
RefSeq:
NP_445912.2
|
| Others |
UniRef100:
UniRef100_Q9EP80
UniRef90:
UniRef90_Q9EP80
UniRef50:
UniRef50_Q9EP80
UniGene:
Rn.24750
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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