Otof - otoferlin-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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84573 Otof

基因描述

Type	Description
Definition	otoferlin

研究结论

Date	Results	Publications
2016-03-12 11:46:00	otoferlin, through GAD65, modulates GABAergic activity.	25701657
2014-05-24 12:40:00	a direct role for otoferlin in exocytosis and modulation of calcium-dependent membrane fusion	24478316
2013-07-27 12:26:00	otoferlin-AP-2 interaction drives Ca(2+)- and stimulus-dependent compensating clathrin-mediated endocytosis in mature inner hair	23719817
2011-06-18 10:10:00	Otof CA domain differs structurally and functionally from other C(2) domains	21216247
2010-01-21 00:00:00	Otoferlin mRNA and protein was detected in mature outer hair cells of low-frequency processing cochlear turns and in auditory nerve fibres. In outer, inner and vestibular hair cells	17229086

名称对应

Type	IDs
Gene	UniProtKB-ID: OTOF_RAT, A0A0G2K867_RAT UniprotKB: Q9ERC5, A0A0G2K867 UniParc: UPI0001B7AD7E, UPI0000DA2A59 EMBL: AF315944, AABR03049539, AABR07063295, AABR03048736 Ensembl: ENSRNOG00000009967 KO: rno:84573
Nucleutide sequences	EMBL-CDS: AAG30298.1 Ensembl_TRS: ENSRNOT00000044278, ENSRNOT00000091159
Protein sequencees	Ensembl_PRO: ENSRNOP00000046997, ENSRNOP00000074490 RefSeq: XP_008762757.1, XP_017449876.1, XP_006239895.1, NP_001263649.1, XP_017449877.1, XP_008762756.1
Others	UniRef100: UniRef100_A0A0G2K867, UniRef100_Q9ERC5 UniRef90: UniRef90_Q9ERC5, UniRef90_Q9HC10 UniRef50: UniRef50_Q9HC10 UniGene: Rn.148993

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mRNA

Protein

UniprotKB

Description

Refseq

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Location

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Pubmed编号	文献信息	发表日期	相关基因
27458190	Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing. EMBO J Christian Vogl , Iliana Panou , Gulnara Yamanbaeva , Carolin Wichmann , Sara J Mangosing , Fabio Vilardi , Artur A Indzhykulian , Tina PangrÅ¡iÄ , Rosamaria Santarelli , Montserrat Rodriguez-Ballesteros , Thomas Weber , Sangyong Jung , Elena Cardenas , Xudong Wu , Sonja M Wojcik , Kelvin Y Kwan , Ignacio Del Castillo , Blanche Schwappach , Nicola Strenzke , David P Corey , Shuh-Yow Lin , Tobias Moser	2016-12-01	-
25701657	Function coupling of otoferlin with GAD65 acts to modulate GABAergic activity. J Mol Cell Biol Wu Wu , Mona N Rahman , Jun Guo , Natalie Roy , Lihua Xue , Catherine M Cahill , Shetuan Zhang , Zongchao Jia	2015-04-01	-
25609709	Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells. J. Cell. Sci. Christian Vogl , Benjamin H Cooper , Jakob Neef , Sonja M Wojcik , Kerstin Reim , Ellen Reisinger , Nils Brose , Jeong-Seop Rhee , Tobias Moser , Carolin Wichmann	2015-02-15	Unc13c, Unc13b, Cadps, Cadps2, Unc13a, Baiap3, Unc13d, Otof
24478316	Calcium regulates molecular interactions of otoferlin with soluble NSF attachment protein receptor (SNARE) proteins required for hair cell exocytosis. J Biol Chem Neeliyath A Ramakrishnan , Marian J Drescher , Barbara J Morley , Philip M Kelley , Dennis G Drescher	2014-03-28	-
23719817	Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells. J. Neurosci. Susanne V Duncker , Christoph Franz , Stephanie Kuhn , Uwe Schulte , Dario Campanelli , Niels Brandt , Bernhard Hirt , Bernd Fakler , Nikolaus Blin , Peter Ruth , Jutta Engel , Walter Marcotti , Ulrike Zimmermann , Marlies Knipper	2013-05-29	-
22906306	Screening of OTOF mutations in Iran: a novel mutation and review. Int. J. Pediatr. Otorhinolaryngol. Nejat Mahdieh , Atefeh Shirkavand , Bahareh Rabbani , Mustafa Tekin , Bahman Akbari , Mohammad Taghi Akbari , Sirous Zeinali	2012-11-01	Otof, OTOF
22575033	A prevalent founder mutation and genotype-phenotype correlations of OTOF in Japanese patients with auditory neuropathy. Clin. Genet. T Matsunaga , H Mutai , S Kunishima , K Namba , N Morimoto , Y Shinjo , Y Arimoto , Y Kataoka , T Shintani , N Morita , T Sugiuchi , S Masuda , A Nakano , H Taiji , K Kaga	2012-11-01	-
22715884	The auditory hair cell ribbon synapse: from assembly to function. Annu. Rev. Neurosci. Saaid Safieddine , Aziz El-Amraoui , Christine Petit	2012-01-01	Slc17a8, Myo6, Otof
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
21216247	The crystal structure of the CâA domain of otoferlin reveals an unconventional top loop region. J. Mol. Biol. Sarah Helfmann , Piotr Neumann , Kai Tittmann , Tobias Moser , Ralf Ficner , Ellen Reisinger	2011-02-25	-

研究热度

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