| Type | Description |
|---|---|
| Definition | forkhead box N1 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-24 14:03:00 | The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity. | 31914405 |
| 2020-06-13 13:05:00 | FOXN1 compound heterozygous mutations cause selective thymic hypoplasia in humans. | 31566583 |
| 2020-04-04 10:44:00 | observations establish a FOXN1 gene dosage effect on thymic function and identify FOXN1 haploinsufficiency as an important genetic determinant of T cell lymphopenia at birth. | 31447097 |
| 2019-03-16 11:04:00 | Here, by engineering a time-delayed feedback system of BMP inhibition in mouse embryos, the authors demonstrate that thymopoiesis irreversibly fails if Foxn1 gene expression does not occur during a defining time span in mid-gestation. They also reveal an epistatic interaction between the extent of BMP signalling and the gene dosage of Foxn1. | 28819138 |
| 2017-09-23 10:33:00 | FOXN1 founder Italian mutation identified in an indian newborn with severe combined immunodeficiency. | 28636882 |
| Type | IDs |
|---|---|
| Synonymous | FKHL20, RONU, WHN |
| Gene |
UniProtKB-ID:
FOXN1_HUMAN
UniprotKB:
O15353
UniParc:
UPI000012ADE6
EMBL:
Y11744,
Y11742,
AK313878,
Y11743,
CH471159,
Y11746,
Y11741,
Y11739,
Y11745
Ensembl:
ENSG00000109101
KO:
hsa:8456
|
| Nucleutide sequences |
EMBL-CDS:
EAW51092.1,
CAA72416.1,
BAG36604.1,
CAA72417.1
Ensembl_TRS:
ENST00000226247,
ENST00000579795
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000464645,
ENSP00000226247
RefSeq:
XP_016880717.1,
XP_011523672.1,
XP_011523660.1,
NP_003584.2,
XP_016880720.1,
XP_011523670.1,
XP_016880719.1,
XP_011523661.1,
NP_001356298.1,
XP_011523664.1,
XP_011523669.1,
XP_011523671.1,
XP_016880718.1
|
| Others |
UniRef100:
UniRef100_O15353
UniRef90:
UniRef90_O15353
UniRef50:
UniRef50_O15353
UniGene:
Hs.663679
CCDS:
CCDS11232.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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