| Type | Description |
|---|---|
| Definition | SLX4 structure-specific endonuclease subunit |
| Date | Results | Publications |
|---|---|---|
| 2020-10-03 12:58:00 | SLX4 interacts with RTEL1 to prevent transcription-mediated DNA replication perturbations. | 32398829 |
| 2019-12-14 11:30:00 | The binding of SLX4IP to both SLX4 and XPF-ERCC1 not only is vital for maintaining the stability of SLX4IP protein, but also promotes the interaction between SLX4 and XPF-ERCC1, especially after DNA damage. Collectively, these results demonstrate a new regulatory role for SLX4IP in maintaining an efficient SLX4-XPF-ERCC1 complex in interstrand crosslinks (ICLs) repair. | 31495888 |
| 2019-04-20 12:04:00 | This review aims at providing an up-to-date and comprehensive view on the key functions that SLX4 fulfills to maintain genome stability as well as to highlight and discuss areas of uncertainty and emerging concepts. [review] | 30284473 |
| 2019-03-02 12:14:00 | RAD52 and SLX4 mediate distinct postreplicative DNA repair processes that maintain ALT telomere stability and cancer cell viability | 30692206 |
| 2018-11-10 11:56:00 | Using or FA-P cells complemented with SLX4 mutants that abrogate interaction with MUS81 or SLX1, we show that SLX4 cooperates with MUS81 to introduce DSBs after replication stress but also counteracts pathological targeting of demised forks by GEN1. | 28290553 |
| Type | IDs |
|---|---|
| Synonymous | BTBD12, FANCP, MUS312 |
| Gene |
UniProtKB-ID:
SLX4_HUMAN
UniprotKB:
Q8IY92
UniParc:
UPI000050D2C5,
UPI00017BE768
EMBL:
AB058687,
AC006111,
AL442083,
AB075867
Ensembl:
ENSG00000188827
KO:
hsa:84464
|
| Nucleutide sequences |
EMBL-CDS:
BAB47413.1,
CAH10659.1,
BAB85573.1
Ensembl_TRS:
ENST00000294008
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000294008
RefSeq:
XP_011521017.1,
XP_024306239.1,
XP_016879264.1,
NP_115820.2
|
| Others |
UniRef100:
UniRef100_Q8IY92
UniRef90:
UniRef90_Q8IY92
UniRef50:
UniRef50_Q8IY92
UniGene:
Hs.143681
CCDS:
CCDS10506.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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