| Type | Description |
|---|---|
| Definition | mitogen-activated protein kinase kinase kinase 21 |
| Date | Results | Publications |
|---|---|---|
| 2020-01-11 11:48:00 | MLK4 was over-expressed in tumor samples of Hepatocellular carcinoma patients. | 31071576 |
| 2019-05-04 10:50:00 | High expression of MLK4 promotes migratory and invasive phenotype. | 30552384 |
| 2018-06-09 10:35:00 | These results suggest that in the early response to stressful stimuli, MLK4beta-MLK3 binding is important for regulating MLK3 activity and MAPK signalling, and after prolonged periods of stress exposure, MLK4beta and MLK3 proteins decline via CHIP-dependent degradation. | 28757353 |
| 2016-06-28 10:33:00 | results uncover MLK4 as an upstream regulator of NF-kappaB signaling and a potential molecular target for the MES subtype of glioblastomas | 26859459 |
| 2013-08-10 11:17:00 | In establishing the role of MLK4 in intracellular signaling, we show it directly phosphorylates MEK1 (MAP2K1) and that MEK/ERK (MAPK1) signaling is impaired in MLK4 knockout cells | 23319808 |
| Type | IDs |
|---|---|
| Synonymous | MLK4, dJ862P8.3 |
| Gene |
UniProtKB-ID:
M3K21_HUMAN
UniprotKB:
Q5TCX8
UniParc:
UPI000013D922,
UPI0000203AA5,
UPI0000203AA4
EMBL:
BC136648,
AL133380,
AJ311798,
AB058707,
CH471098,
AJ311797,
BC136649
Ensembl:
ENSG00000143674
KO:
hsa:84451
|
| Nucleutide sequences |
EMBL-CDS:
EAW69988.1,
AAI36649.1,
BAB47433.1,
CAC84639.1,
AAI36650.1,
CAC84640.1
Ensembl_TRS:
ENST00000366624,
ENST00000366623,
ENST00000366622
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000355581,
ENSP00000355583,
ENSP00000355582
RefSeq:
XP_011542607.1,
NP_115811.2
|
| Others |
UniRef100:
UniRef100_Q5TCX8
UniRef90:
UniRef90_Q5TCX8
UniRef50:
UniRef50_Q5TCX8
UniGene:
Hs.547779
CCDS:
CCDS1598.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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