| Type | Description |
|---|---|
| Definition | nuclear receptor subfamily 0 group B member 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-01-19 10:37:00 | Loss of SHP expression is associated with nonalcoholic steatohepatitis. | 29666185 |
| 2018-12-22 12:06:00 | results suggest that NR0B2 is a tumor suppressor gene in ccRCC, and that the hypermethylation of promoter region is the main mechanism of its downregulation. | 29989580 |
| 2018-10-27 11:01:00 | DDX3 regulates MTP gene expression and lipid homeostasis through interplay with HNF4 and SHP. | 28128295 |
| 2018-10-06 11:09:00 | The miR-141 was significantly up-regulated in the samples of metastatic tumors compared to localized tumor samples. Tumor samples showed lower SHP mRNA expression levels than BPH samples. | 29562494 |
| 2018-07-14 10:10:00 | The impact of these variants on transactivation of the NR0B2 promoter by NRs known to be regulators of SHP1 expression was assessed in a cell-based reporter gene assay, showing that transactivation by hepatocyte nuclear factor 4alpha and liver receptor homolog-1 was significantly decreased in the presence of the genetic variant NR0B2:c.-594T> | 28873070 |
| Type | IDs |
|---|---|
| Synonymous | SHP, SHP1 |
| Gene |
UniProtKB-ID:
NR0B2_HUMAN
UniprotKB:
Q15466
UniParc:
UPI0000135956
EMBL:
L76571,
HQ692833,
AL356390,
AB058644,
BC030207,
CH471059
Ensembl:
ENSG00000131910
KO:
hsa:8431
|
| Nucleutide sequences |
EMBL-CDS:
AAC41998.1,
AAH30207.1,
BAB68530.1,
ADZ17344.1,
EAX07781.1
Ensembl_TRS:
ENST00000254227
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000254227
RefSeq:
NP_068804.1,
XP_011540599.1
|
| Others |
UniRef100:
UniRef100_Q15466
UniRef90:
UniRef90_Q15466
UniRef50:
UniRef50_Q15466
UniGene:
Hs.427055
CCDS:
CCDS291.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员