| Type | Description |
|---|---|
| Definition | nudix hydrolase 16 like 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-08-17 10:42:00 | X-ray crystal structures of TIRR and a designer protein bound to 53BP1 now reveal a mechanism in which an intricate binding area centered on an essential TIRR arginine residue blocks the methylated-chromatin-binding surface of 53BP1. A 53BP1 separation-of-function mutation that abolishes TIRR-mediated regulation in cells renders 53BP1 hyperactive in response to DSBs, highlighting the key inhibitory function of TIRR. | 29967538 |
| 2019-07-27 10:58:00 | Identification of a small subset of mRNAs responsible for the biogenesis of primary cilium that have been linked to developmental and degenerative diseases, known as ciliopathies, and cancer. SDOS binds and regulates the translation of several of these mRNAs, controlling cilia development. | 30260431 |
| 2018-12-22 11:09:00 | This study elucidates the mechanism by which TIRR recognizes 53BP1 Tudor and functions as a cellular inhibitor of the histone methyl-lysine readers. | 29844495 |
| 2018-12-22 10:13:00 | Data indicate the molecular mechanism underlying Tudor interacting repair regulator (TIRR)-mediated suppression of tumor protein p53 binding protein 1 (53BP1)-dependent DNA damage repair. | 30002377 |
| 2017-08-09 18:37:00 | findings identify TIRR as a new factor that influences double-strand break repair using a unique mechanism of masking the histone methyl-lysine binding function of 53BP1 | 28241136 |
| Type | IDs |
|---|---|
| Synonymous | SDOS |
| Gene |
UniProtKB-ID:
TIRR_HUMAN,
B2RD96_HUMAN,
W4VSQ8_HUMAN
UniprotKB:
Q9BRJ7,
B2RD96,
W4VSQ8
UniParc:
UPI0000EE6720,
UPI0000071EB2,
UPI000006F550,
UPI00017507EE
EMBL:
AC023830,
BC006223,
CH471112,
AK315456,
AK092642
Ensembl:
ENSG00000168101
KO:
hsa:84309
|
| Nucleutide sequences |
EMBL-CDS:
BAC03933.1,
AAH06223.1,
BAG37843.1,
EAW85278.1
Gene_ORFName:
hCG_15176
Ensembl_TRS:
ENST00000405142,
ENST00000304301,
ENST00000586536
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000458144,
ENSP00000306670,
ENSP00000468346
RefSeq:
NP_001357516.1,
NP_001357517.1,
NP_115725.1,
NP_001357514.1,
XP_005255690.1,
NP_001180381.1,
NP_001357515.1
|
| Others |
UniRef100:
UniRef100_B2RD96,
UniRef100_Q9BRJ7,
UniRef100_W4VSQ8
UniRef90:
UniRef90_Q3MHX9,
UniRef90_A0A5G2QSV7,
UniRef90_Q9BRJ7
UniRef50:
UniRef50_Q8VHN8-2,
UniRef50_Q9BRJ7,
UniRef50_Q9BRJ7-2
UniGene:
Hs.513315
CCDS:
CCDS10519.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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