| Type | Description |
|---|---|
| Definition | latent transforming growth factor beta binding protein 4 |
| Date | Results | Publications |
|---|---|---|
| 2019-12-14 11:29:00 | an AMPK-LTBP4 axis in inflammatory macrophages controls the production of TGF-beta1, which is further activated by and acts on fibroblastic cells, leading to fibrosis in Duchenne muscular dystrophy. | 30463013 |
| 2018-10-27 10:26:00 | DMD gene mutations involving the hinge 3 region, actin-binding domain, and exons 45-49, as well as the LTBP4 IAAM haplotype, were not associated with age of left ventricular dysfunction onset inDuchenne muscular dystrophy. | 29766838 |
| 2017-09-09 10:36:00 | High LTBP4 expression is associated with recurrence in glioblastoma. | 27270107 |
| 2017-08-19 10:09:00 | Studied the potential role of LTBP-4 in scleroderma through clinical, in vivo and in vitro studies. Results suggest that LTBP-4 protein level is increased in plasma and skin tissue of scleroderma patients; found LTBP-4 to be a potential biomarker to differentiate systemic scleroderma (SSc) from localized scleroderma (LSc) patients. | 28263294 |
| 2016-07-30 11:12:00 | The LTBP4 VTTT allele is associated with increased risk of dilated cardiomyopathy in European Americans. LTBP4 protein with the IAAM residues bound more latent TGFbeta compared to the LTBP4 VTTT protein. | 26918958 |
| Type | IDs |
|---|---|
| Synonymous | ARCL1C, LTBP-4, LTBP4L, LTBP4S |
| Gene |
UniProtKB-ID:
LTBP4_HUMAN,
A0A0C4DH07_HUMAN,
B3KXY6_HUMAN
UniprotKB:
Q8N2S1,
A0A0C4DH07,
B3KXY6
UniParc:
UPI0000DACAC6,
UPI00004A2930,
UPI00015E0F9A,
UPI0000D617A7,
UPI0000DACAC1,
UPI0000DACAC4
EMBL:
KF459702,
AK128191,
AC010412,
AF051345,
AF051344,
AK074499,
Y13622
Ensembl:
ENSG00000090006
KO:
hsa:8425
|
| Nucleutide sequences |
EMBL-CDS:
AAC39879.2,
AAC39880.2,
CAA73944.1,
BAC11024.1,
BAG54648.1
Ensembl_TRS:
ENST00000308370,
ENST00000396819,
ENST00000204005
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000311905,
ENSP00000380031,
ENSP00000204005
RefSeq:
NP_001036009.1,
NP_001036010.1,
NP_003564.2
|
| Others |
UniRef100:
UniRef100_Q8N2S1,
UniRef100_A0A0C4DH07
UniRef90:
UniRef90_Q8N2S1-3,
UniRef90_Q8N2S1
UniRef50:
UniRef50_Q8N2S1
UniGene:
Hs.466766
CCDS:
CCDS74368.1,
CCDS74369.1,
CCDS74370.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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