| Type | Description |
|---|---|
| Definition | MAF1 homolog, negative regulator of RNA polymerase III |
| Date | Results | Publications |
|---|---|---|
| 2020-07-18 12:17:00 | results identify the ubiquitin proteasome pathway and CUL2 as important regulators of MAF1 levels; they suggest that decreases in MAF1 protein underlie chemoresistance in HCC and perhaps other cancers and point to an important role for MAF1 and RNA pol III-mediated transcription in chemosensitivity and apoptosis | 31645432 |
| 2020-04-18 11:00:00 | Structural basis for RNA polymerase III transcription repression by Maf1 in humans and yeast has been uncovered. | 32066962 |
| 2019-05-25 12:06:00 | High expression levels of MAF1 homolog, negative regulator of RNA Pol III (MAF1) is associated with advanced tumor depth, lymph node metastasis, distant metastasis and poor prognosis of colorectal cancer (CRC). MAF1 knockdown suppresses chemoresistance and migration of CRC cancer cells. High expression levels of MAF1 is an independent prognostic indicator in microsatellite instabilitypositive CRC. | 30628658 |
| 2017-07-22 13:28:00 | can act as a transcriptional activator for PTEN, which is important for MAF1's tumor-suppressor function | 26910647 |
| 2017-03-18 12:37:00 | Repression of Pol III recruitment and transcription are tightly linked to MAF1, which selectively localizes at Pol III loci, even under serum-replete conditions, and increasingly targets transcribing Pol III in response to serum starvation | 26941251 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
MAF1_HUMAN
UniprotKB:
Q9H063
UniParc:
UPI0000140E10
EMBL:
BC014082,
BC031273,
AC104592,
CH471162,
BC018714,
AL136937,
CR533463
Ensembl:
ENSG00000179632
KO:
hsa:84232
|
| Nucleutide sequences |
EMBL-CDS:
CAG38494.1,
AAH18714.1,
AAH14082.1,
EAW82159.1,
CAB66871.1,
AAH31273.1,
EAW82158.1
Ensembl_TRS:
ENST00000532522,
ENST00000322428
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000436720,
ENSP00000318604
RefSeq:
NP_115648.2
|
| Others |
UniRef100:
UniRef100_Q9H063
UniRef90:
UniRef90_Q9H063
UniRef50:
UniRef50_Q9H063
UniGene:
Hs.19673
CCDS:
CCDS6416.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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