| Type | Description |
|---|---|
| Definition | ATR interacting protein |
| Date | Results | Publications |
|---|---|---|
| 2016-12-17 10:59:00 | ATRIP deacetylation by SIRT2 promotes ATR-ATRIP binding to replication protein A-single-stranded DNA to drive ATR activation and thus facilitate recovery from replication stress. | 26854234 |
| 2014-09-06 12:41:00 | ATRIP SUMOylation promotes ATR activation by providing a unique type of protein glue that boosts multiple protein interactions along the ATR pathway | 24990965 |
| 2014-02-15 10:10:00 | Data on crystal structure of BRCA1 binding with phosphopeptides suggest that C-terminal domain of BRCA1 interacts with ATRIP and BAAT1 with preferences for specific side chains; in ATRIP, phospho-Ser239 and Phe242 are the main interacting residues. | 24073851 |
| 2013-05-25 10:34:00 | Data indicate that ATRIP is a direct target gene of HIF-1, and the increased ATRIP then activates the ATR signaling pathway under hypoxia. | 23454212 |
| 2013-05-18 10:32:00 | our analysis exposes an overlapping clinical manifestation between the disorders but allows an expanded spectrum of clinical features for ATR-ATRIP Seckel Syndrome to be defined | 23144622 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
ATRIP_HUMAN,
A0A024R2U4_HUMAN,
A0A024R307_HUMAN
UniprotKB:
Q8WXE1,
A0A024R2U4,
A0A024R307
UniParc:
UPI0000376A9E,
UPI000206595F,
UPI0000070A6A,
UPI000006FEF2
EMBL:
AF451323,
AK022405,
AK300548,
BC020563,
AK291568,
AL832917,
AK291829,
CH471055,
AC104448,
BC014153,
AK315075,
BC030597
Ensembl:
ENSG00000164053
KO:
hsa:84126
|
| Nucleutide sequences |
EMBL-CDS:
BAB14029.1,
BAF84518.1,
AAH30597.1,
AAH14153.2,
CAH10621.1,
AAH20563.1,
EAW64878.1,
EAW64876.1,
BAF84257.1,
AAL38042.1,
BAG37544.1,
BAG62254.1,
EAW64880.1,
EAW64879.1
Gene_ORFName:
hCG_1997849,
hCG_1997849
Ensembl_TRS:
ENST00000412052,
ENST00000357105,
ENST00000346691,
ENST00000320211
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000302338,
ENSP00000349620,
ENSP00000323099,
ENSP00000400930
RefSeq:
NP_001257952.1,
NP_001257951.1,
NP_115542.2,
NP_569055.1
|
| Others |
UniRef100:
UniRef100_A0A024R307,
UniRef100_Q8WXE1
UniRef90:
UniRef90_Q8WXE1
UniRef50:
UniRef50_Q8WXE1
UniGene:
Hs.694840
CCDS:
CCDS2768.1,
CCDS59450.1,
CCDS59449.1,
CCDS2767.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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